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Dynamic Evolution of the Glymphatic System at the Early Stages of Subarachnoid Hemorrhage

The early stages of subarachnoid hemorrhage (SAH) are extremely important for the progression and prognosis of this disease. The glymphatic system (GS) has positive implications for the nervous system due to its ability to clearance tau and amyloid-β (Aβ) protein. Previous studies have shown that GS...

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Autores principales: Hou, Changkai, Li, Jian, Wang, Bangyue, Liu, Quanlei, Zhao, Yan, Zhang, Hao, Wang, Weihan, Ren, Wen, Cui, Xiaopeng, Yang, Xinyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283644/
https://www.ncbi.nlm.nih.gov/pubmed/35847203
http://dx.doi.org/10.3389/fneur.2022.924080
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author Hou, Changkai
Li, Jian
Wang, Bangyue
Liu, Quanlei
Zhao, Yan
Zhang, Hao
Wang, Weihan
Ren, Wen
Cui, Xiaopeng
Yang, Xinyu
author_facet Hou, Changkai
Li, Jian
Wang, Bangyue
Liu, Quanlei
Zhao, Yan
Zhang, Hao
Wang, Weihan
Ren, Wen
Cui, Xiaopeng
Yang, Xinyu
author_sort Hou, Changkai
collection PubMed
description The early stages of subarachnoid hemorrhage (SAH) are extremely important for the progression and prognosis of this disease. The glymphatic system (GS) has positive implications for the nervous system due to its ability to clearance tau and amyloid-β (Aβ) protein. Previous studies have shown that GS dysfunction will appear after SAH. However, there is no systematic evaluation of the degree of damage and development process of GS function in the early stage after SAH. In this study, we evaluated the GS function and neurobehavioral in the sham, 6 h, 1, 3, and 7 days after SAH, respectively. Our results showed that the function of GS was severely attenuated in mice after SAH with a decreased polarity of Aquaporin-4 (AQP4), increased expression of AQP4, a linear correlation with the dystrophin-associated complex (DAC), the proliferation of reactive astrocytes, increased tau protein accumulation, and decreased neurological function. Collectively, these findings provide a comprehensive understanding of the functional changes of GS after SAH, provide references for subsequent scholars studying SAH, and suggest some potential mechanistic insight that affects AQP4 polarity and GS function.
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spelling pubmed-92836442022-07-16 Dynamic Evolution of the Glymphatic System at the Early Stages of Subarachnoid Hemorrhage Hou, Changkai Li, Jian Wang, Bangyue Liu, Quanlei Zhao, Yan Zhang, Hao Wang, Weihan Ren, Wen Cui, Xiaopeng Yang, Xinyu Front Neurol Neurology The early stages of subarachnoid hemorrhage (SAH) are extremely important for the progression and prognosis of this disease. The glymphatic system (GS) has positive implications for the nervous system due to its ability to clearance tau and amyloid-β (Aβ) protein. Previous studies have shown that GS dysfunction will appear after SAH. However, there is no systematic evaluation of the degree of damage and development process of GS function in the early stage after SAH. In this study, we evaluated the GS function and neurobehavioral in the sham, 6 h, 1, 3, and 7 days after SAH, respectively. Our results showed that the function of GS was severely attenuated in mice after SAH with a decreased polarity of Aquaporin-4 (AQP4), increased expression of AQP4, a linear correlation with the dystrophin-associated complex (DAC), the proliferation of reactive astrocytes, increased tau protein accumulation, and decreased neurological function. Collectively, these findings provide a comprehensive understanding of the functional changes of GS after SAH, provide references for subsequent scholars studying SAH, and suggest some potential mechanistic insight that affects AQP4 polarity and GS function. Frontiers Media S.A. 2022-07-01 /pmc/articles/PMC9283644/ /pubmed/35847203 http://dx.doi.org/10.3389/fneur.2022.924080 Text en Copyright © 2022 Hou, Li, Wang, Liu, Zhao, Zhang, Wang, Ren, Cui and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Hou, Changkai
Li, Jian
Wang, Bangyue
Liu, Quanlei
Zhao, Yan
Zhang, Hao
Wang, Weihan
Ren, Wen
Cui, Xiaopeng
Yang, Xinyu
Dynamic Evolution of the Glymphatic System at the Early Stages of Subarachnoid Hemorrhage
title Dynamic Evolution of the Glymphatic System at the Early Stages of Subarachnoid Hemorrhage
title_full Dynamic Evolution of the Glymphatic System at the Early Stages of Subarachnoid Hemorrhage
title_fullStr Dynamic Evolution of the Glymphatic System at the Early Stages of Subarachnoid Hemorrhage
title_full_unstemmed Dynamic Evolution of the Glymphatic System at the Early Stages of Subarachnoid Hemorrhage
title_short Dynamic Evolution of the Glymphatic System at the Early Stages of Subarachnoid Hemorrhage
title_sort dynamic evolution of the glymphatic system at the early stages of subarachnoid hemorrhage
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283644/
https://www.ncbi.nlm.nih.gov/pubmed/35847203
http://dx.doi.org/10.3389/fneur.2022.924080
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