A randomized, cross‐over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence

There are limited comparison data throughout the dosing interval for generic versus brand metoprolol extended‐release (ER) tablets. We compared the pharmacokinetics (PKs) and pharmacodynamics of brand name versus two generic formulations (drugs 1 and 2) of metoprolol ER tablets with different time t...

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Detalles Bibliográficos
Autores principales: Mosley, Scott A., Kim, Sarah, El Rouby, Nihal, Lingineni, Karthik, Esteban, Valvanera Vozmediano, Gong, Yan, Chen, Yiqing, Estores, David, Feng, Kairui, Kim, Hyewon, Kinjo, Minori, Langaee, Taimour, Li, Zhichuan, Schmidt, Siegfried O. F., Johnson, Julie A., Frye, Reginald F., Fang, Lanyan (Lucy), Zhao, Liang, Binkley, Philip F., Schmidt, Stephan, Cavallari, Larisa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283731/
https://www.ncbi.nlm.nih.gov/pubmed/35488487
http://dx.doi.org/10.1111/cts.13294

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