Influence of CYP2D6 genetic variation on adverse events with propafenone in the pediatric and young adult population

Propafenone is an antiarrhythmic drug metabolized primarily by cytochrome P450 2D6 (CYP2D6). In adults, propafenone adverse events (AEs) are associated with CYP2D6 poor metabolizer status; however, pediatric data are lacking. Subjects were tested for 10 CYP2D6 allelic variants and copy number status...

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Detalles Bibliográficos
Autores principales: Sunthankar, Sudeep D., Kannankeril, Prince J., Gaedigk, Andrea, Radbill, Andrew E., Fish, Frank A., Van Driest, Sara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283732/
https://www.ncbi.nlm.nih.gov/pubmed/35514162
http://dx.doi.org/10.1111/cts.13296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283732/
https://www.ncbi.nlm.nih.gov/pubmed/35514162
http://dx.doi.org/10.1111/cts.13296

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