Cargando…

IL-6 gene rs1800795 polymorphism and diabetes mellitus: a comprehensive analysis involving 42,150 participants from a meta-analysis

BACKGROUND: Over the past two decades, several studies have focused on the association between a common polymorphism (rs1800795) from interleukin-6 (IL-6) gene and Diabetes Mellitus (DM) risk. However, the results remain ambiguous and indefinite. METHODS: A comprehensive analysis was performed to ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Zhiying, Zhang, Chunmin, Mi, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283852/
https://www.ncbi.nlm.nih.gov/pubmed/35840989
http://dx.doi.org/10.1186/s13098-022-00851-8
_version_ 1784747421580918784
author Cheng, Zhiying
Zhang, Chunmin
Mi, Yuanyuan
author_facet Cheng, Zhiying
Zhang, Chunmin
Mi, Yuanyuan
author_sort Cheng, Zhiying
collection PubMed
description BACKGROUND: Over the past two decades, several studies have focused on the association between a common polymorphism (rs1800795) from interleukin-6 (IL-6) gene and Diabetes Mellitus (DM) risk. However, the results remain ambiguous and indefinite. METHODS: A comprehensive analysis was performed to explore this relationship. A search was conducted in the PubMed, Embase, Chinese (CNKI and Wanfang), and GWAS Catalog databases, covering all publications until February 10, 2022. Odds ratios (OR) with 95% confidence intervals (CI) were used to evaluate the strength of the association. Publication bias was assessed using both Begg and Egger tests. RESULTS: Overall, 34 case–control studies with 7257 T2DM patients and 15,598 controls, and 12 case–control studies (10,264 T1DM patients and 9031 health controls) were included in the analysis. A significantly lower association was observed between the rs1800795 polymorphism and T2DM risk in Asians, mixed population, and hospital-based (HB) subgroups (C-allele vs. G-allele: OR = 0.76, 95% CI  0.58–0.99, P = 0.039 for Asians; CG vs. GG: OR = 0.74, 95% CI  0.58–0.94, P = 0.014 for mixed population; CC vs. GG: OR = 0.61, 95% CI  0.41–0.90, P = 0.014 for HB). However, increased associations were found from total, mixed population, and HB subgroups between rs1800795 polymorphism and T1DM susceptibility (CG vs. GG: OR = 1.32, 95% CI 1.01–1.74, P = 0.043 for total population, CC vs. GG: OR = 2.45, 95% CI 1.18–5.07, P = 0.016 for mixed individuals; C-allele vs. G-allele: OR = 1.29, 95% CI 1.07–1.56, P = 0.0009 for HB subgroup). CONCLUSIONS: In summary, there is definite evidence to confirm that IL-6 rs1800795 polymorphism is associated with susceptibility to decreased T2DM and increased T1DM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13098-022-00851-8.
format Online
Article
Text
id pubmed-9283852
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-92838522022-07-15 IL-6 gene rs1800795 polymorphism and diabetes mellitus: a comprehensive analysis involving 42,150 participants from a meta-analysis Cheng, Zhiying Zhang, Chunmin Mi, Yuanyuan Diabetol Metab Syndr Research BACKGROUND: Over the past two decades, several studies have focused on the association between a common polymorphism (rs1800795) from interleukin-6 (IL-6) gene and Diabetes Mellitus (DM) risk. However, the results remain ambiguous and indefinite. METHODS: A comprehensive analysis was performed to explore this relationship. A search was conducted in the PubMed, Embase, Chinese (CNKI and Wanfang), and GWAS Catalog databases, covering all publications until February 10, 2022. Odds ratios (OR) with 95% confidence intervals (CI) were used to evaluate the strength of the association. Publication bias was assessed using both Begg and Egger tests. RESULTS: Overall, 34 case–control studies with 7257 T2DM patients and 15,598 controls, and 12 case–control studies (10,264 T1DM patients and 9031 health controls) were included in the analysis. A significantly lower association was observed between the rs1800795 polymorphism and T2DM risk in Asians, mixed population, and hospital-based (HB) subgroups (C-allele vs. G-allele: OR = 0.76, 95% CI  0.58–0.99, P = 0.039 for Asians; CG vs. GG: OR = 0.74, 95% CI  0.58–0.94, P = 0.014 for mixed population; CC vs. GG: OR = 0.61, 95% CI  0.41–0.90, P = 0.014 for HB). However, increased associations were found from total, mixed population, and HB subgroups between rs1800795 polymorphism and T1DM susceptibility (CG vs. GG: OR = 1.32, 95% CI 1.01–1.74, P = 0.043 for total population, CC vs. GG: OR = 2.45, 95% CI 1.18–5.07, P = 0.016 for mixed individuals; C-allele vs. G-allele: OR = 1.29, 95% CI 1.07–1.56, P = 0.0009 for HB subgroup). CONCLUSIONS: In summary, there is definite evidence to confirm that IL-6 rs1800795 polymorphism is associated with susceptibility to decreased T2DM and increased T1DM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13098-022-00851-8. BioMed Central 2022-07-15 /pmc/articles/PMC9283852/ /pubmed/35840989 http://dx.doi.org/10.1186/s13098-022-00851-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Cheng, Zhiying
Zhang, Chunmin
Mi, Yuanyuan
IL-6 gene rs1800795 polymorphism and diabetes mellitus: a comprehensive analysis involving 42,150 participants from a meta-analysis
title IL-6 gene rs1800795 polymorphism and diabetes mellitus: a comprehensive analysis involving 42,150 participants from a meta-analysis
title_full IL-6 gene rs1800795 polymorphism and diabetes mellitus: a comprehensive analysis involving 42,150 participants from a meta-analysis
title_fullStr IL-6 gene rs1800795 polymorphism and diabetes mellitus: a comprehensive analysis involving 42,150 participants from a meta-analysis
title_full_unstemmed IL-6 gene rs1800795 polymorphism and diabetes mellitus: a comprehensive analysis involving 42,150 participants from a meta-analysis
title_short IL-6 gene rs1800795 polymorphism and diabetes mellitus: a comprehensive analysis involving 42,150 participants from a meta-analysis
title_sort il-6 gene rs1800795 polymorphism and diabetes mellitus: a comprehensive analysis involving 42,150 participants from a meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283852/
https://www.ncbi.nlm.nih.gov/pubmed/35840989
http://dx.doi.org/10.1186/s13098-022-00851-8
work_keys_str_mv AT chengzhiying il6geners1800795polymorphismanddiabetesmellitusacomprehensiveanalysisinvolving42150participantsfromametaanalysis
AT zhangchunmin il6geners1800795polymorphismanddiabetesmellitusacomprehensiveanalysisinvolving42150participantsfromametaanalysis
AT miyuanyuan il6geners1800795polymorphismanddiabetesmellitusacomprehensiveanalysisinvolving42150participantsfromametaanalysis