A biosensor of protein foldedness identifies increased “holdase” activity of chaperones in the nucleus following increased cytosolic protein aggregation

Chaperones and other quality control machinery guard proteins from inappropriate aggregation, which is a hallmark of neurodegenerative diseases. However, how the systems that regulate the “foldedness” of the proteome remain buffered under stress conditions and in different cellular compartments rema...

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Detalles Bibliográficos
Autores principales: Raeburn, Candice B., Ormsby, Angelique R., Cox, Dezerae, Gerak, Chloe A., Makhoul, Christian, Moily, Nagaraj S., Ebbinghaus, Simon, Dickson, Alex, McColl, Gawain, Hatters, Danny M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283929/
https://www.ncbi.nlm.nih.gov/pubmed/35724963
http://dx.doi.org/10.1016/j.jbc.2022.102158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283929/
https://www.ncbi.nlm.nih.gov/pubmed/35724963
http://dx.doi.org/10.1016/j.jbc.2022.102158

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