Cargando…
The Role of Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target
Autoimmune diseases are a series of diseases involving multiple tissues and organs, characterized by the over production of abnormal multiple antibodies. Although most studies support that the impaired immune balance participates in the development of autoimmune diseases, the specific pathogenesis o...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284064/ https://www.ncbi.nlm.nih.gov/pubmed/35844539 http://dx.doi.org/10.3389/fimmu.2022.871713 |
_version_ | 1784747473621745664 |
---|---|
author | An, Jia Liu, Yuqing Wang, Yiqi Fan, Ru Hu, Xiaorong Zhang, Fen Yang, Jinhua Chen, Junwei |
author_facet | An, Jia Liu, Yuqing Wang, Yiqi Fan, Ru Hu, Xiaorong Zhang, Fen Yang, Jinhua Chen, Junwei |
author_sort | An, Jia |
collection | PubMed |
description | Autoimmune diseases are a series of diseases involving multiple tissues and organs, characterized by the over production of abnormal multiple antibodies. Although most studies support that the impaired immune balance participates in the development of autoimmune diseases, the specific pathogenesis of it is not fully understood. Intestinal immunity, especially the intestinal mucosal barrier has become a research hotspot, which is considered to be an upstream mechanism leading to the impaired immune balance. As an important defense barrier, the intestinal mucosal barrier regulates and maintains the homeostasis of internal environment. Once the intestinal barrier function is impaired under the effect of multiple factors, it will destroy the immune homeostasis, trigger inflammatory response, and participate in the development of autoimmune diseases in the final. However, the mechanism of the intestinal mucosal barrier how to regulate the homeostasis and inflammation is not clear. Some studies suggest that it maintains the balance of immune homeostasis through the zonulin pathway, intestinal microbiome, and Toll-like receptor signaling pathway. Our review focused on the composition and the function of the intestinal mucosal barrier to describe the research progress of it in regulating the immune homeostasis and inflammation, and also pointed that the intestinal mucosal barrier was the potential targets in the treatment of autoimmune diseases. |
format | Online Article Text |
id | pubmed-9284064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92840642022-07-16 The Role of Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target An, Jia Liu, Yuqing Wang, Yiqi Fan, Ru Hu, Xiaorong Zhang, Fen Yang, Jinhua Chen, Junwei Front Immunol Immunology Autoimmune diseases are a series of diseases involving multiple tissues and organs, characterized by the over production of abnormal multiple antibodies. Although most studies support that the impaired immune balance participates in the development of autoimmune diseases, the specific pathogenesis of it is not fully understood. Intestinal immunity, especially the intestinal mucosal barrier has become a research hotspot, which is considered to be an upstream mechanism leading to the impaired immune balance. As an important defense barrier, the intestinal mucosal barrier regulates and maintains the homeostasis of internal environment. Once the intestinal barrier function is impaired under the effect of multiple factors, it will destroy the immune homeostasis, trigger inflammatory response, and participate in the development of autoimmune diseases in the final. However, the mechanism of the intestinal mucosal barrier how to regulate the homeostasis and inflammation is not clear. Some studies suggest that it maintains the balance of immune homeostasis through the zonulin pathway, intestinal microbiome, and Toll-like receptor signaling pathway. Our review focused on the composition and the function of the intestinal mucosal barrier to describe the research progress of it in regulating the immune homeostasis and inflammation, and also pointed that the intestinal mucosal barrier was the potential targets in the treatment of autoimmune diseases. Frontiers Media S.A. 2022-07-01 /pmc/articles/PMC9284064/ /pubmed/35844539 http://dx.doi.org/10.3389/fimmu.2022.871713 Text en Copyright © 2022 An, Liu, Wang, Fan, Hu, Zhang, Yang and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology An, Jia Liu, Yuqing Wang, Yiqi Fan, Ru Hu, Xiaorong Zhang, Fen Yang, Jinhua Chen, Junwei The Role of Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target |
title | The Role of Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target |
title_full | The Role of Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target |
title_fullStr | The Role of Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target |
title_full_unstemmed | The Role of Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target |
title_short | The Role of Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target |
title_sort | role of intestinal mucosal barrier in autoimmune disease: a potential target |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284064/ https://www.ncbi.nlm.nih.gov/pubmed/35844539 http://dx.doi.org/10.3389/fimmu.2022.871713 |
work_keys_str_mv | AT anjia theroleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT liuyuqing theroleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT wangyiqi theroleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT fanru theroleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT huxiaorong theroleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT zhangfen theroleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT yangjinhua theroleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT chenjunwei theroleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT anjia roleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT liuyuqing roleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT wangyiqi roleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT fanru roleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT huxiaorong roleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT zhangfen roleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT yangjinhua roleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget AT chenjunwei roleofintestinalmucosalbarrierinautoimmunediseaseapotentialtarget |