Cargando…

Soft, Dynamic Hydrogel Confinement Improves Kidney Organoid Lumen Morphology and Reduces Epithelial–Mesenchymal Transition in Culture

Pluripotent stem cell‐derived kidney organoids offer a promising solution to renal failure, yet current organoid protocols often lead to off‐target cells and phenotypic alterations, preventing maturity. Here, various dynamic hydrogel architectures are created, conferring a controlled and biomimetic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruiter, Floor A. A., Morgan, Francis L. C., Roumans, Nadia, Schumacher, Anika, Slaats, Gisela G., Moroni, Lorenzo, LaPointe, Vanessa L. S., Baker, Matthew B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284132/ https://www.ncbi.nlm.nih.gov/pubmed/35567354 http://dx.doi.org/10.1002/advs.202200543

Ejemplares similares

Enhanced Microvasculature Formation and Patterning in iPSC–Derived Kidney Organoids Cultured in Physiological Hypoxia
por: Schumacher, Anika, et al.
Publicado: (2022)

Methodological approaches in aggregate formation and microscopic analysis to assess pseudoislet morphology and cellular interactions
por: Wieland, Fredrik, et al.
Publicado: (2022)

Optimization of Media Change Intervals through Hydrogels Using Mathematical Models
por: Ruiter, Floor A.A., et al.
Publicado: (2023)

Modular mixing of benzene-1,3,5-tricarboxamide supramolecular hydrogelators allows tunable biomimetic hydrogels for control of cell aggregation in 3D
por: Hafeez, Shahzad, et al.
Publicado: (2022)

Overcoming kidney organoid challenges for regenerative medicine
por: Geuens, Thomas, et al.
Publicado: (2020)

A comparative study of mesenchymal stem cells cultured as cell‐only aggregates and in encapsulated hydrogels
por: Passanha, Fiona R., et al.
Publicado: (2021)

Autophagy, not apoptosis, plays a role in lumen formation of eccrine gland organoids
por: Du, Lijie, et al.
Publicado: (2022)

Cell confinement controls centrosome positioning and lumen initiation during epithelial morphogenesis
por: Rodríguez-Fraticelli, Alejo E., et al.
Publicado: (2012)

Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures
por: Urciuolo, Anna, et al.
Publicado: (2023)

Fibrous hydrogels under biaxial confinement
por: Li, Yang, et al.
Publicado: (2022)

Complementary Supramolecular Functionalization Enhances Antifouling Surfaces: A Ureidopyrimidinone-Functionalized Phosphorylcholine Polymer
por: Feliciano, Antonio J., et al.
Publicado: (2023)

Injectable Therapeutic Organoids Using Sacrificial Hydrogels
por: Rossen, Ninna S., et al.
Publicado: (2020)

Recent advances in defined hydrogels in organoid research
por: Gan, Zhongqiao, et al.
Publicado: (2023)

Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids
por: Sen, Dilara, et al.
Publicado: (2021)

Universal behavior of hydrogels confined to narrow capillaries
por: Li, Yang, et al.
Publicado: (2015)

OrganoidChip facilitates hydrogel-free immobilization for fast and blur-free imaging of organoids
por: Moshksayan, Khashayar, et al.
Publicado: (2023)

Magnetically assisted soft milli-tools for occluded lumen morphology detection
por: Yan, Yingbo, et al.
Publicado: (2023)

Fabrication of lumen-forming colorectal cancer organoids using a newly designed laminin-derived bioink
por: Pérez-Pedroza, Rosario, et al.
Publicado: (2022)

Remotely Triggered Locomotion of Hydrogel Mag-bots in Confined Spaces
por: Shen, Tong, et al.
Publicado: (2017)

Brain organoid formation on decellularized porcine brain ECM hydrogels
por: Simsa, Robin, et al.
Publicado: (2021)

The Confining String from the Soft Dilaton Theorem
por: Alvarez, Enrique, et al.
Publicado: (1999)

Bio‐assembling Macro‐Scale, Lumenized Airway Tubes of Defined Shape via Multi‐Organoid Patterning and Fusion
por: Liu, Ye, et al.
Publicado: (2021)

The Changing Integrin Expression and a Role for Integrin β8 in the Chondrogenic Differentiation of Mesenchymal Stem Cells
por: LaPointe, Vanessa L. S., et al.
Publicado: (2013)

Cadherin-11 Influences Differentiation in Human Mesenchymal Stem Cells by Regulating the Extracellular Matrix Via the TGFβ1 Pathway
por: Passanha, Fiona R, et al.
Publicado: (2022)

12th Workshop on Soft Physics : strong interaction at large distances, confinement
por: Bugrij, G V, et al.
Publicado: (1996)

The role of nonlinear mechanical properties of biomimetic hydrogels for organoid growth
por: Buchmann, Benedikt, et al.
Publicado: (2021)

A Chemically Defined Hydrogel for Human Liver Organoid Culture
por: Ye, Shicheng, et al.
Publicado: (2020)

Self-Assembled Hydrogel Microparticle-Based Tooth-Germ Organoids
por: Kilic Bektas, Cemile, et al.
Publicado: (2022)

Role of immediate early genes in the development of salivary gland organoids in polyisocyanopeptide hydrogels
por: Schaafsma, Paulien, et al.
Publicado: (2023)

Visualizing thermal distribution through hydrogel confined ionic system
por: Gui, Qinyuan, et al.
Publicado: (2021)

Delivery of Mesenchymal Stem Cells from Gelatin–Alginate Hydrogels to Stomach Lumen for Treatment of Gastroparesis
por: Joddar, Binata, et al.
Publicado: (2018)

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
por: Du, Xuewen, et al.
Publicado: (2015)

Biomimetic Mechanically Strong One-Dimensional Hydroxyapatite/Poly(d,l-lactide) Composite Inducing Formation of Anisotropic Collagen Matrix
por: Zhang, Yonggang, et al.
Publicado: (2021)

Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media
por: Latreille, Pierre-Luc, et al.
Publicado: (2019)

A single-cell RNA-seq analysis unravels the heterogeneity of primary cultured human corneal endothelial cells
por: Català, Pere, et al.
Publicado: (2023)

Synthetic Hydrogels for Human Intestinal Organoid Generation and Colonic Wound Repair
por: Cruz-Acuña, Ricardo, et al.
Publicado: (2017)

Hydrogel-based milliwell arrays for standardized and scalable retinal organoid cultures
por: Decembrini, S., et al.
Publicado: (2020)

Polyisocyanide Hydrogels as a Tunable Platform for Mammary Gland Organoid Formation
por: Zhang, Ying, et al.
Publicado: (2020)

Engineered Plant‐Based Nanocellulose Hydrogel for Small Intestinal Organoid Growth
por: Curvello, Rodrigo, et al.
Publicado: (2020)

Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids
por: Kim, Suran, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_o3itff0kcpopht4nb2rbb19nt3