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Outcomes of patients with different lepidic percentage and tumor size of stage I lung adenocarcinoma
BACKGROUND: To evaluate the long‐term outcomes after surgical resection for stage I lung adenocarcinoma based on the percentage of lepidic component (LC) and invasive tumor size (IS). METHODS: The clinicopathological characteristics of 1049 patients with stage I lung adenocarcinoma who underwent sur...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284188/ https://www.ncbi.nlm.nih.gov/pubmed/35680127 http://dx.doi.org/10.1111/1759-7714.14477 |
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author | Liu, Chia Wang, Lei‐Chi Chen, Hui‐Shan Yeh, Yi‐Chen Hsu, Po‐Kuei Huang, Chien‐Sheng Hsieh, Chih‐Cheng Hsu, Han‐Shui |
author_facet | Liu, Chia Wang, Lei‐Chi Chen, Hui‐Shan Yeh, Yi‐Chen Hsu, Po‐Kuei Huang, Chien‐Sheng Hsieh, Chih‐Cheng Hsu, Han‐Shui |
author_sort | Liu, Chia |
collection | PubMed |
description | BACKGROUND: To evaluate the long‐term outcomes after surgical resection for stage I lung adenocarcinoma based on the percentage of lepidic component (LC) and invasive tumor size (IS). METHODS: The clinicopathological characteristics of 1049 patients with stage I lung adenocarcinoma who underwent surgery between 2006 and 2016 were retrospectively reviewed. Tumors were categorized into groups: A (LC ≥ 50%) and B (LC < 50%). Groups A0 and A1 consisted of minimally invasive adenocarcinomas (MIA) and other lepidic‐predominant invasive adenocarcinomas, respectively. Group B was categorized into B1 (IS ≤ 1 cm), B2 (1 < IS≤2 cm), and B3 (2 < IS≤3 cm) by invasive tumor size and divided into subgroups (B1[lep+]/[lep−], B2[lep+]/[lep−], and B3[lep+]/[lep−]) according to the presence[lep+] or absence[lep−] of LCs. Cumulative incidence of recurrence (CIR) and cancer‐specific survival (CSS) were examined. RESULTS: LC decreased with increasing IS. Only 24 (8.5%) tumors in group A had an IS >1 cm. 10‐year CIR and CSS were 15.2% and 86.0%. LC and IS were found to be independent predictors of CSS. Patients in group A had 1.4% 10‐year CIR and 100% 10‐year CSS. In group B, a significantly higher CIR and worse CSS were observed as IS increased (p < 0.001), but LC was not a predictor for CSS (p = 0.593). No significant differences in CIR or CSS were found in presence of LC or not when LC < 50% (B1[lep+]/[lep−], B2[lep+]/[lep−], and B3[lep+]/[lep−]: p = 0.36/0.48, p = 0.82/0.94, and p = 0.90/0.37, respectively). CONCLUSIONS: LC≥50% tumors demonstrated excellent prognosis regardless of IS. The outcomes of LC < 50% tumors were well predicted by IS, corresponding to the T‐staging system. The predictive value of LC for prognosis became insignificant. |
format | Online Article Text |
id | pubmed-9284188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-92841882022-07-15 Outcomes of patients with different lepidic percentage and tumor size of stage I lung adenocarcinoma Liu, Chia Wang, Lei‐Chi Chen, Hui‐Shan Yeh, Yi‐Chen Hsu, Po‐Kuei Huang, Chien‐Sheng Hsieh, Chih‐Cheng Hsu, Han‐Shui Thorac Cancer Original Articles BACKGROUND: To evaluate the long‐term outcomes after surgical resection for stage I lung adenocarcinoma based on the percentage of lepidic component (LC) and invasive tumor size (IS). METHODS: The clinicopathological characteristics of 1049 patients with stage I lung adenocarcinoma who underwent surgery between 2006 and 2016 were retrospectively reviewed. Tumors were categorized into groups: A (LC ≥ 50%) and B (LC < 50%). Groups A0 and A1 consisted of minimally invasive adenocarcinomas (MIA) and other lepidic‐predominant invasive adenocarcinomas, respectively. Group B was categorized into B1 (IS ≤ 1 cm), B2 (1 < IS≤2 cm), and B3 (2 < IS≤3 cm) by invasive tumor size and divided into subgroups (B1[lep+]/[lep−], B2[lep+]/[lep−], and B3[lep+]/[lep−]) according to the presence[lep+] or absence[lep−] of LCs. Cumulative incidence of recurrence (CIR) and cancer‐specific survival (CSS) were examined. RESULTS: LC decreased with increasing IS. Only 24 (8.5%) tumors in group A had an IS >1 cm. 10‐year CIR and CSS were 15.2% and 86.0%. LC and IS were found to be independent predictors of CSS. Patients in group A had 1.4% 10‐year CIR and 100% 10‐year CSS. In group B, a significantly higher CIR and worse CSS were observed as IS increased (p < 0.001), but LC was not a predictor for CSS (p = 0.593). No significant differences in CIR or CSS were found in presence of LC or not when LC < 50% (B1[lep+]/[lep−], B2[lep+]/[lep−], and B3[lep+]/[lep−]: p = 0.36/0.48, p = 0.82/0.94, and p = 0.90/0.37, respectively). CONCLUSIONS: LC≥50% tumors demonstrated excellent prognosis regardless of IS. The outcomes of LC < 50% tumors were well predicted by IS, corresponding to the T‐staging system. The predictive value of LC for prognosis became insignificant. John Wiley & Sons Australia, Ltd 2022-06-09 2022-07 /pmc/articles/PMC9284188/ /pubmed/35680127 http://dx.doi.org/10.1111/1759-7714.14477 Text en © 2022 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Liu, Chia Wang, Lei‐Chi Chen, Hui‐Shan Yeh, Yi‐Chen Hsu, Po‐Kuei Huang, Chien‐Sheng Hsieh, Chih‐Cheng Hsu, Han‐Shui Outcomes of patients with different lepidic percentage and tumor size of stage I lung adenocarcinoma |
title | Outcomes of patients with different lepidic percentage and tumor size of stage I lung adenocarcinoma |
title_full | Outcomes of patients with different lepidic percentage and tumor size of stage I lung adenocarcinoma |
title_fullStr | Outcomes of patients with different lepidic percentage and tumor size of stage I lung adenocarcinoma |
title_full_unstemmed | Outcomes of patients with different lepidic percentage and tumor size of stage I lung adenocarcinoma |
title_short | Outcomes of patients with different lepidic percentage and tumor size of stage I lung adenocarcinoma |
title_sort | outcomes of patients with different lepidic percentage and tumor size of stage i lung adenocarcinoma |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284188/ https://www.ncbi.nlm.nih.gov/pubmed/35680127 http://dx.doi.org/10.1111/1759-7714.14477 |
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