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Irinotecan dose reduction in metastatic colorectal cancer patients with homozygous UGT1A1*28 polymorphism: a single-center case series

OBJECTIVE: The UGT1A1*28 polymorphism reduces UGT1A1 enzymatic activity, which may increase the risk of severe toxicity in patients who receive standard-dose irinotecan, such as severe neutropenia and diarrhea. This real-world study assessed the optimal irinotecan dose in terms of efficacy and toxic...

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Detalles Bibliográficos
Autores principales:	Tsai, Hsiang-Lin, Chen, Po-Jung, Chen, Yen-Cheng, Li, Ching-Chun, Chang, Tsung-Kun, Su, Wei-Chih, Yin, Tzu-Chieh, Huang, Ching-Wen, Wang, Jaw-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2022
Materias:	Case Series
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284221/ https://www.ncbi.nlm.nih.gov/pubmed/35822291 http://dx.doi.org/10.1177/03000605221110697

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