Cargando…
The Relationship Between the Tumor Cell Expression of Hypoxic Markers and Survival in Patients With ER-positive Invasive Ductal Breast Cancer
The prognostic significance of hypoxia markers, hypoxia-inducible factor-1α (HIF-1α), hypoxia-inducible factor-2α (HIF-2α), and carbonic anhydrase IX (CAIX), was investigated in estrogen receptor (ER)-positive breast cancer patients. Immunohistochemistry determined the expression of makers in two in...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284237/ https://www.ncbi.nlm.nih.gov/pubmed/35792080 http://dx.doi.org/10.1369/00221554221110280 |
_version_ | 1784747520746848256 |
---|---|
author | Shamis, Suad A.K. Quinn, Jean Mallon, Elizabeth E.A. Edwards, Joanne McMillan, Donald C. |
author_facet | Shamis, Suad A.K. Quinn, Jean Mallon, Elizabeth E.A. Edwards, Joanne McMillan, Donald C. |
author_sort | Shamis, Suad A.K. |
collection | PubMed |
description | The prognostic significance of hypoxia markers, hypoxia-inducible factor-1α (HIF-1α), hypoxia-inducible factor-2α (HIF-2α), and carbonic anhydrase IX (CAIX), was investigated in estrogen receptor (ER)-positive breast cancer patients. Immunohistochemistry determined the expression of makers in two independent ductal ER-positive cohorts (Training set, n=373 and Validation set, n=285) and was related to clinicopathological parameters and disease-free survival (DFS). In the training cohort, nuclear HIF-1α (1) was independently associated with poorer DFS in luminal A tumors [hazard ratio (HR) = 0.53 95% confidence interval (CI): 0.30–0.94, p=0.030]. In the validation cohort, both HIF-1α (1) and CAIX were independently associated with decreased DFS in the entire cohort (HR = 1.85 95% CI: 1.10–3.11, p=0.019; HR = 1.74 95% CI: 1.08–2.82, p=0.023), in luminal A disease (HR = 1.98 95% CI: 1.02–3.83, p=0.042), and in luminal B disease (HR = 2.75 95% CI: 1.66–4.55, p<0.001), respectively. Taken together, elevated cytoplasmic HIF-1α (1) expression was an independent prognostic factor in luminal A disease, whereas CAIX was an independent prognostic factor in luminal B disease. Further work in large tissue cohorts is required. |
format | Online Article Text |
id | pubmed-9284237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-92842372022-07-29 The Relationship Between the Tumor Cell Expression of Hypoxic Markers and Survival in Patients With ER-positive Invasive Ductal Breast Cancer Shamis, Suad A.K. Quinn, Jean Mallon, Elizabeth E.A. Edwards, Joanne McMillan, Donald C. J Histochem Cytochem Articles The prognostic significance of hypoxia markers, hypoxia-inducible factor-1α (HIF-1α), hypoxia-inducible factor-2α (HIF-2α), and carbonic anhydrase IX (CAIX), was investigated in estrogen receptor (ER)-positive breast cancer patients. Immunohistochemistry determined the expression of makers in two independent ductal ER-positive cohorts (Training set, n=373 and Validation set, n=285) and was related to clinicopathological parameters and disease-free survival (DFS). In the training cohort, nuclear HIF-1α (1) was independently associated with poorer DFS in luminal A tumors [hazard ratio (HR) = 0.53 95% confidence interval (CI): 0.30–0.94, p=0.030]. In the validation cohort, both HIF-1α (1) and CAIX were independently associated with decreased DFS in the entire cohort (HR = 1.85 95% CI: 1.10–3.11, p=0.019; HR = 1.74 95% CI: 1.08–2.82, p=0.023), in luminal A disease (HR = 1.98 95% CI: 1.02–3.83, p=0.042), and in luminal B disease (HR = 2.75 95% CI: 1.66–4.55, p<0.001), respectively. Taken together, elevated cytoplasmic HIF-1α (1) expression was an independent prognostic factor in luminal A disease, whereas CAIX was an independent prognostic factor in luminal B disease. Further work in large tissue cohorts is required. SAGE Publications 2022-07-06 2022-07 /pmc/articles/PMC9284237/ /pubmed/35792080 http://dx.doi.org/10.1369/00221554221110280 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Articles Shamis, Suad A.K. Quinn, Jean Mallon, Elizabeth E.A. Edwards, Joanne McMillan, Donald C. The Relationship Between the Tumor Cell Expression of Hypoxic Markers and Survival in Patients With ER-positive Invasive Ductal Breast Cancer |
title | The Relationship Between the Tumor Cell Expression of Hypoxic Markers
and Survival in Patients With ER-positive Invasive Ductal Breast
Cancer |
title_full | The Relationship Between the Tumor Cell Expression of Hypoxic Markers
and Survival in Patients With ER-positive Invasive Ductal Breast
Cancer |
title_fullStr | The Relationship Between the Tumor Cell Expression of Hypoxic Markers
and Survival in Patients With ER-positive Invasive Ductal Breast
Cancer |
title_full_unstemmed | The Relationship Between the Tumor Cell Expression of Hypoxic Markers
and Survival in Patients With ER-positive Invasive Ductal Breast
Cancer |
title_short | The Relationship Between the Tumor Cell Expression of Hypoxic Markers
and Survival in Patients With ER-positive Invasive Ductal Breast
Cancer |
title_sort | relationship between the tumor cell expression of hypoxic markers
and survival in patients with er-positive invasive ductal breast
cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284237/ https://www.ncbi.nlm.nih.gov/pubmed/35792080 http://dx.doi.org/10.1369/00221554221110280 |
work_keys_str_mv | AT shamissuadak therelationshipbetweenthetumorcellexpressionofhypoxicmarkersandsurvivalinpatientswitherpositiveinvasiveductalbreastcancer AT quinnjean therelationshipbetweenthetumorcellexpressionofhypoxicmarkersandsurvivalinpatientswitherpositiveinvasiveductalbreastcancer AT mallonelizabethea therelationshipbetweenthetumorcellexpressionofhypoxicmarkersandsurvivalinpatientswitherpositiveinvasiveductalbreastcancer AT edwardsjoanne therelationshipbetweenthetumorcellexpressionofhypoxicmarkersandsurvivalinpatientswitherpositiveinvasiveductalbreastcancer AT mcmillandonaldc therelationshipbetweenthetumorcellexpressionofhypoxicmarkersandsurvivalinpatientswitherpositiveinvasiveductalbreastcancer AT shamissuadak relationshipbetweenthetumorcellexpressionofhypoxicmarkersandsurvivalinpatientswitherpositiveinvasiveductalbreastcancer AT quinnjean relationshipbetweenthetumorcellexpressionofhypoxicmarkersandsurvivalinpatientswitherpositiveinvasiveductalbreastcancer AT mallonelizabethea relationshipbetweenthetumorcellexpressionofhypoxicmarkersandsurvivalinpatientswitherpositiveinvasiveductalbreastcancer AT edwardsjoanne relationshipbetweenthetumorcellexpressionofhypoxicmarkersandsurvivalinpatientswitherpositiveinvasiveductalbreastcancer AT mcmillandonaldc relationshipbetweenthetumorcellexpressionofhypoxicmarkersandsurvivalinpatientswitherpositiveinvasiveductalbreastcancer |