Cargando…

Elucidation of the Application of Blood Test Biomarkers to Predict Immune-Related Adverse Events in Atezolizumab-Treated NSCLC Patients Using Machine Learning Methods

BACKGROUND: Development of severe immune-related adverse events (irAEs) is a major predicament to stop treatment with immune checkpoint inhibitors, even though tumor progression is suppressed. However, no effective early phase biomarker has been established to predict irAE until now. METHOD: This st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Jian-Guo, Wong, Ada Hang-Heng, Wang, Haitao, Tan, Fangya, Chen, Xiaofei, Jin, Su-Han, He, Si-Si, Shen, Gang, Wang, Yun-Jia, Frey, Benjamin, Fietkau, Rainer, Hecht, Markus, Ma, Hu, Gaipl, Udo S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284319/ https://www.ncbi.nlm.nih.gov/pubmed/35844547 http://dx.doi.org/10.3389/fimmu.2022.862752

Ejemplares similares

Definition of a new blood cell count score for early survival prediction for non-small cell lung cancer patients treated with atezolizumab: Integrated analysis of four multicenter clinical trials
por: Zhou, Jian-Guo, et al.
Publicado: (2022)

Immune biological rationales for the design of combined radio- and immunotherapies
por: Hader, Michael, et al.
Publicado: (2020)

Definitive Radiochemotherapie von lokal fortgeschrittenen Kopf-Hals-Tumoren in Kombination mit Immuncheckpointinhibition – neue Konzepte gefragt
por: Hecht, Markus, et al.
Publicado: (2021)

Chemoradiation Increases PD-L1 Expression in Certain Melanoma and Glioblastoma Cells
por: Derer, Anja, et al.
Publicado: (2016)

Development of a Modular Assay for Detailed Immunophenotyping of Peripheral Human Whole Blood Samples by Multicolor Flow Cytometry
por: Rühle, Paul F., et al.
Publicado: (2016)

Identification of 15 lncRNAs Signature for Predicting Survival Benefit of Advanced Melanoma Patients Treated with Anti-PD-1 Monotherapy
por: Zhou, Jian-Guo, et al.
Publicado: (2021)

Low-Dose Radiotherapy Has No Harmful Effects on Key Cells of Healthy Non-Inflamed Joints
por: Deloch, Lisa, et al.
Publicado: (2018)

Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses – Pre-Clinical Evidence and Ongoing Clinical Applications
por: Derer, Anja, et al.
Publicado: (2015)

Low-Dose Irradiation Differentially Impacts Macrophage Phenotype in Dependence of Fibroblast-Like Synoviocytes and Radiation Dose
por: Deloch, Lisa, et al.
Publicado: (2019)

Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation
por: Deloch, Lisa, et al.
Publicado: (2016)

Combinations of Radiotherapy with Vaccination and Immune Checkpoint Inhibition Differently Affect Primary and Abscopal Tumor Growth and the Tumor Microenvironment
por: Rückert, Michael, et al.
Publicado: (2021)

Identification of an endogenous retroviral signature to predict anti-PD1 response in advanced clear cell renal cell carcinoma: an integrated analysis of three clinical trials
por: Zhou, Jian-Guo, et al.
Publicado: (2022)

The Influence of Radiation on Bone and Bone Cells—Differential Effects on Osteoclasts and Osteoblasts
por: Donaubauer, Anna-Jasmina, et al.
Publicado: (2020)

Atezolizumab-Induced Aseptic Meningitis in Patients with NSCLC
por: Toyozawa, Ryo, et al.
Publicado: (2020)

Identification and characterization of circular RNAs as novel putative biomarkers to predict anti-PD-1 monotherapy response in metastatic melanoma patients – Knowledge from two independent international studies
por: Zhou, Jian-Guo, et al.
Publicado: (2023)

Clinically Relevant Radiation Exposure Differentially Impacts Forms of Cell Death in Human Cells of the Innate and Adaptive Immune System
por: Falcke, Sylvia E., et al.
Publicado: (2018)

Normofractionated irradiation and not temozolomide modulates the immunogenic and oncogenic phenotype of human glioblastoma cell lines
por: Schatz, Julia, et al.
Publicado: (2022)

Modulations in the Peripheral Immune System of Glioblastoma Patient Is Connected to Therapy and Tumor Progression—A Case Report from the IMMO-GLIO-01 Trial
por: Rühle, Paul F., et al.
Publicado: (2017)

Die Bedeutung der Strahlentherapie im Kontext immer effektiver werdender Systemtherapien beim metastasierten NSCLC – Hinweise aus einer Rezidivanalyse nach Immuncheckpointinhibitoren
por: Schubert, Philipp, et al.
Publicado: (2021)

Hypofractionated Radiotherapy Upregulates Several Immune Checkpoint Molecules in Head and Neck Squamous Cell Carcinoma Cells Independently of the HPV Status While ICOS-L Is Upregulated Only on HPV-Positive Cells
por: Wimmer, Sebastian, et al.
Publicado: (2021)

The in vitro immunogenic potential of caspase-3 proficient breast cancer cells with basal low immunogenicity is increased by hypofractionated irradiation
por: Kötter, Bernhard, et al.
Publicado: (2015)

12 × 6 Gy stereotactic radiotherapy for lung tumors. Is there a difference in response between lung metastases and primary bronchial carcinoma?
por: Lubgan, Dorota, et al.
Publicado: (2021)

Prospective Evaluation of CD45RA+/CCR7- Effector Memory T (T(EMRA)) Cell Subsets in Patients with Primary and Secondary Brain Tumors during Radiotherapy of the Brain within the Scope of the Prospective Glio-CMV-01 Clinical Trial
por: Scheer, Ilka, et al.
Publicado: (2023)

Radiotherapy combined with docetaxel alters the immune phenotype of HNSCC cells and results in increased surface expression of CD137 and release of HMGB1 of specifically HPV-positive tumor cells
por: Grottker, Fridolin, et al.
Publicado: (2023)

Questionnaire-based detection of immune-related adverse events in cancer patients treated with PD-1/PD-L1 immune checkpoint inhibitors
por: Griewing, Luisa Maria, et al.
Publicado: (2021)

Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines
por: Rubner, Yvonne, et al.
Publicado: (2014)

Editorial: Immune-Related Adverse Events for Patients With Lung Cancer
por: Yang, Ruoning, et al.
Publicado: (2022)

Editorial: Immune-related adverse events for patients with lung cancer-volume II
por: Wang, Yusha, et al.
Publicado: (2023)

Prospective Evaluation of All-lesion Versus Single-lesion Radiotherapy in Combination With PD-1/PD-L1 Immune Checkpoint Inhibitors
por: Schubert, Philipp, et al.
Publicado: (2020)

Hypofractionated Irradiation Has Immune Stimulatory Potential and Induces a Timely Restricted Infiltration of Immune Cells in Colon Cancer Tumors
por: Frey, Benjamin, et al.
Publicado: (2017)

Head and neck tumor cells treated with hypofractionated irradiation die via apoptosis and are better taken up by M1-like macrophages
por: Wedekind, Hanna, et al.
Publicado: (2021)

A Phase 2 Study of Atezolizumab for Pretreated NSCLC With Idiopathic Interstitial Pneumonitis
por: Ikeda, Satoshi, et al.
Publicado: (2020)

A 5-Genomic Mutation Signature Can Predict the Survival for Patients With NSCLC Receiving Atezolizumab
por: Lin, Jiamao, et al.
Publicado: (2021)

Tumor-specific radiosensitizing effect of the ATM inhibitor AZD0156 in melanoma cells with low toxicity to healthy fibroblasts
por: Scheper, Julian, et al.
Publicado: (2022)

Low Dose Radiation Therapy, Particularly with 0.5 Gy, Improves Pain in Degenerative Joint Disease of the Fingers: Results of a Retrospective Analysis
por: Donaubauer, Anna-Jasmina, et al.
Publicado: (2020)

Prospective development and validation of a liquid immune profile-based signature (LIPS) to predict response of patients with recurrent/metastatic cancer to immune checkpoint inhibitors
por: Zhou, Jian-Guo, et al.
Publicado: (2021)

Editorial to Radiation in Multimodal Tumor Immune Therapies—Mechanisms and Application
por: Frey, Benjamin, et al.
Publicado: (2021)

Predictive Value of Multiparametric MRI for Response to Single-Cycle Induction Chemo-Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma
por: Hellwig, Konstantin, et al.
Publicado: (2021)

Low-Dose Radiotherapy Leads to a Systemic Anti-Inflammatory Shift in the Pre-Clinical K/BxN Serum Transfer Model and Reduces Osteoarthritic Pain in Patients
por: Weissmann, Thomas, et al.
Publicado: (2022)

How Does Ionizing Irradiation Contribute to the Induction of Anti-Tumor Immunity?
por: Rubner, Yvonne, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_4kvmcipsocr5kf20augc1uduv7