Cargando…
Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer
NFE2L3, also known as NFE2L3, is a nuclear transcription factor associated with the pathogenesis and progression of human tumors. To systematically and comprehensively investigate the role of NFE2L3 in tumors, a pan-cancer analysis was performed using multi-omics data, including gene expression anal...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284341/ https://www.ncbi.nlm.nih.gov/pubmed/35846126 http://dx.doi.org/10.3389/fgene.2022.916973 |
_version_ | 1784747539916914688 |
---|---|
author | Liu, Mengxiao Wei, Hui Yang, Jing Chen, Xia Wang, Haoying Zheng, Ya Wang, Yuping Zhou, Yongning |
author_facet | Liu, Mengxiao Wei, Hui Yang, Jing Chen, Xia Wang, Haoying Zheng, Ya Wang, Yuping Zhou, Yongning |
author_sort | Liu, Mengxiao |
collection | PubMed |
description | NFE2L3, also known as NFE2L3, is a nuclear transcription factor associated with the pathogenesis and progression of human tumors. To systematically and comprehensively investigate the role of NFE2L3 in tumors, a pan-cancer analysis was performed using multi-omics data, including gene expression analysis, diagnostic and prognostic analysis, epigenetic methylation analysis, gene alteration analysis, immune feature analysis, functional enrichment analysis, and tumor cell functional status analysis. Furthermore, the molecular mechanism of NFE2L3 in liver hepatocellular carcinoma (LIHC) was explored. The relationship between NFE2L3 expression and survival prognosis of patients with LIHC was analyzed and a nomogram prediction model was constructed. Our study showed that NFE2L3 expression was upregulated in most cancers, suggesting that NFE2L3 may play an important role in promoting cancer progression. NFE2L3 expression is closely related to DNA methylation, genetic alteration, immune signature, and tumor cell functional status in pan-cancers. Furthermore, NFE2L3 was demonstrated to be an independent risk factor for LIHC, and the nomogram model based on NFE2L3 expression had good prediction efficiency for the overall survival of patients with LIHC. In summary, our study indicated that NFE2L3 may be an important molecular biomarker for the diagnosis and prognosis of pan-cancer. NFE2L3 is expected to be a potential molecular target for the treatment of tumors. |
format | Online Article Text |
id | pubmed-9284341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92843412022-07-16 Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer Liu, Mengxiao Wei, Hui Yang, Jing Chen, Xia Wang, Haoying Zheng, Ya Wang, Yuping Zhou, Yongning Front Genet Genetics NFE2L3, also known as NFE2L3, is a nuclear transcription factor associated with the pathogenesis and progression of human tumors. To systematically and comprehensively investigate the role of NFE2L3 in tumors, a pan-cancer analysis was performed using multi-omics data, including gene expression analysis, diagnostic and prognostic analysis, epigenetic methylation analysis, gene alteration analysis, immune feature analysis, functional enrichment analysis, and tumor cell functional status analysis. Furthermore, the molecular mechanism of NFE2L3 in liver hepatocellular carcinoma (LIHC) was explored. The relationship between NFE2L3 expression and survival prognosis of patients with LIHC was analyzed and a nomogram prediction model was constructed. Our study showed that NFE2L3 expression was upregulated in most cancers, suggesting that NFE2L3 may play an important role in promoting cancer progression. NFE2L3 expression is closely related to DNA methylation, genetic alteration, immune signature, and tumor cell functional status in pan-cancers. Furthermore, NFE2L3 was demonstrated to be an independent risk factor for LIHC, and the nomogram model based on NFE2L3 expression had good prediction efficiency for the overall survival of patients with LIHC. In summary, our study indicated that NFE2L3 may be an important molecular biomarker for the diagnosis and prognosis of pan-cancer. NFE2L3 is expected to be a potential molecular target for the treatment of tumors. Frontiers Media S.A. 2022-06-29 /pmc/articles/PMC9284341/ /pubmed/35846126 http://dx.doi.org/10.3389/fgene.2022.916973 Text en Copyright © 2022 Liu, Wei, Yang, Chen, Wang, Zheng, Wang and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Liu, Mengxiao Wei, Hui Yang, Jing Chen, Xia Wang, Haoying Zheng, Ya Wang, Yuping Zhou, Yongning Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer |
title | Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer |
title_full | Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer |
title_fullStr | Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer |
title_full_unstemmed | Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer |
title_short | Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer |
title_sort | multi-omics analysis of molecular characteristics and carcinogenic effect of nfe2l3 in pan-cancer |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284341/ https://www.ncbi.nlm.nih.gov/pubmed/35846126 http://dx.doi.org/10.3389/fgene.2022.916973 |
work_keys_str_mv | AT liumengxiao multiomicsanalysisofmolecularcharacteristicsandcarcinogeniceffectofnfe2l3inpancancer AT weihui multiomicsanalysisofmolecularcharacteristicsandcarcinogeniceffectofnfe2l3inpancancer AT yangjing multiomicsanalysisofmolecularcharacteristicsandcarcinogeniceffectofnfe2l3inpancancer AT chenxia multiomicsanalysisofmolecularcharacteristicsandcarcinogeniceffectofnfe2l3inpancancer AT wanghaoying multiomicsanalysisofmolecularcharacteristicsandcarcinogeniceffectofnfe2l3inpancancer AT zhengya multiomicsanalysisofmolecularcharacteristicsandcarcinogeniceffectofnfe2l3inpancancer AT wangyuping multiomicsanalysisofmolecularcharacteristicsandcarcinogeniceffectofnfe2l3inpancancer AT zhouyongning multiomicsanalysisofmolecularcharacteristicsandcarcinogeniceffectofnfe2l3inpancancer |