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Preferences for pre-exposure prophylaxis for HIV: A systematic review of discrete choice experiments

BACKGROUND: We aimed to systematically review the health preference literature using discrete choice experiments (DCEs), an attribute-based stated preference method, to investigate patient preferences for HIV pre-exposure prophylaxis (PrEP). METHODS: A search in PubMed, Scopus, CINAHL, and Embase wa...

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Autores principales: Wulandari, Luh Putu Lila, He, Shi Yi, Fairley, Christopher K., Bavinton, Benjamin R., Marie-Schmidt, Heather, Wiseman, Virginia, Guy, Rebecca, Tang, Weiming, Zhang, Lei, Ong, Jason J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284393/
https://www.ncbi.nlm.nih.gov/pubmed/35844771
http://dx.doi.org/10.1016/j.eclinm.2022.101507
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author Wulandari, Luh Putu Lila
He, Shi Yi
Fairley, Christopher K.
Bavinton, Benjamin R.
Marie-Schmidt, Heather
Wiseman, Virginia
Guy, Rebecca
Tang, Weiming
Zhang, Lei
Ong, Jason J.
author_facet Wulandari, Luh Putu Lila
He, Shi Yi
Fairley, Christopher K.
Bavinton, Benjamin R.
Marie-Schmidt, Heather
Wiseman, Virginia
Guy, Rebecca
Tang, Weiming
Zhang, Lei
Ong, Jason J.
author_sort Wulandari, Luh Putu Lila
collection PubMed
description BACKGROUND: We aimed to systematically review the health preference literature using discrete choice experiments (DCEs), an attribute-based stated preference method, to investigate patient preferences for HIV pre-exposure prophylaxis (PrEP). METHODS: A search in PubMed, Scopus, CINAHL, and Embase was conducted on July 1, 2021, and updated on November 3, 2021. We used two concepts to create our search strategy: (1) discrete choice experiments/conjoint analysis/best-worst scaling, and (2) HIV PrEP.The study is registered in PROSPERO (CRD42021267026). FINDINGS: In total, 1060 studies were identified, and 18 were included in the analysis. Various attributes were examined, including dosing regimen, type of PrEP products, side effects, other side benefits, cost, effectiveness, dispensing venue, and additional support services. Dosing frequency, cost, the effectiveness of PrEP, dispensing venue, and side effects were the most common attributes examined in DCEs. Despite significant heterogeneity in preferences across subpopulations, overall, the most important attributes were cost (28%, 5/18), effectiveness (28%, 5/18) followed by dosing frequency (17%, 3/18). INTERPRETATION: Notably, in studies where all of these three attributes were examined, some individuals would trade effectiveness for cost or vice versa. Ensuring PrEP is low cost or free, widely disseminating information of its effectiveness and advancements in reducing dosing frequency could accelerate the uptake of PrEP for those who would benefit from PrEP the most. FUNDING: None.
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spelling pubmed-92843932022-07-16 Preferences for pre-exposure prophylaxis for HIV: A systematic review of discrete choice experiments Wulandari, Luh Putu Lila He, Shi Yi Fairley, Christopher K. Bavinton, Benjamin R. Marie-Schmidt, Heather Wiseman, Virginia Guy, Rebecca Tang, Weiming Zhang, Lei Ong, Jason J. eClinicalMedicine Review BACKGROUND: We aimed to systematically review the health preference literature using discrete choice experiments (DCEs), an attribute-based stated preference method, to investigate patient preferences for HIV pre-exposure prophylaxis (PrEP). METHODS: A search in PubMed, Scopus, CINAHL, and Embase was conducted on July 1, 2021, and updated on November 3, 2021. We used two concepts to create our search strategy: (1) discrete choice experiments/conjoint analysis/best-worst scaling, and (2) HIV PrEP.The study is registered in PROSPERO (CRD42021267026). FINDINGS: In total, 1060 studies were identified, and 18 were included in the analysis. Various attributes were examined, including dosing regimen, type of PrEP products, side effects, other side benefits, cost, effectiveness, dispensing venue, and additional support services. Dosing frequency, cost, the effectiveness of PrEP, dispensing venue, and side effects were the most common attributes examined in DCEs. Despite significant heterogeneity in preferences across subpopulations, overall, the most important attributes were cost (28%, 5/18), effectiveness (28%, 5/18) followed by dosing frequency (17%, 3/18). INTERPRETATION: Notably, in studies where all of these three attributes were examined, some individuals would trade effectiveness for cost or vice versa. Ensuring PrEP is low cost or free, widely disseminating information of its effectiveness and advancements in reducing dosing frequency could accelerate the uptake of PrEP for those who would benefit from PrEP the most. FUNDING: None. Elsevier 2022-07-09 /pmc/articles/PMC9284393/ /pubmed/35844771 http://dx.doi.org/10.1016/j.eclinm.2022.101507 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Wulandari, Luh Putu Lila
He, Shi Yi
Fairley, Christopher K.
Bavinton, Benjamin R.
Marie-Schmidt, Heather
Wiseman, Virginia
Guy, Rebecca
Tang, Weiming
Zhang, Lei
Ong, Jason J.
Preferences for pre-exposure prophylaxis for HIV: A systematic review of discrete choice experiments
title Preferences for pre-exposure prophylaxis for HIV: A systematic review of discrete choice experiments
title_full Preferences for pre-exposure prophylaxis for HIV: A systematic review of discrete choice experiments
title_fullStr Preferences for pre-exposure prophylaxis for HIV: A systematic review of discrete choice experiments
title_full_unstemmed Preferences for pre-exposure prophylaxis for HIV: A systematic review of discrete choice experiments
title_short Preferences for pre-exposure prophylaxis for HIV: A systematic review of discrete choice experiments
title_sort preferences for pre-exposure prophylaxis for hiv: a systematic review of discrete choice experiments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284393/
https://www.ncbi.nlm.nih.gov/pubmed/35844771
http://dx.doi.org/10.1016/j.eclinm.2022.101507
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