Methionine synthase supports tumor tetrahydrofolate pools

Mammalian cells require activated folates to generate nucleotides for growth and division. The most abundant circulating folate species is 5-methyl tetrahydrofolate (5-methyl-THF), which is used to synthesize methionine from homocysteine via the cobalamin-dependent enzyme methionine synthase (MTR)....

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Detalles Bibliográficos
Autores principales: Ghergurovich, Jonathan M., Xu, Xincheng, Wang, Joshua Z., Yang, Lifeng, Ryseck, Rolf-Peter, Wang, Lin, Rabinowitz, Joshua D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284419/
https://www.ncbi.nlm.nih.gov/pubmed/34799699
http://dx.doi.org/10.1038/s42255-021-00465-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284419/
https://www.ncbi.nlm.nih.gov/pubmed/34799699
http://dx.doi.org/10.1038/s42255-021-00465-w

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