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Methionine synthase supports tumor tetrahydrofolate pools

Mammalian cells require activated folates to generate nucleotides for growth and division. The most abundant circulating folate species is 5-methyl tetrahydrofolate (5-methyl-THF), which is used to synthesize methionine from homocysteine via the cobalamin-dependent enzyme methionine synthase (MTR)....

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Detalles Bibliográficos
Autores principales:	Ghergurovich, Jonathan M., Xu, Xincheng, Wang, Joshua Z., Yang, Lifeng, Ryseck, Rolf-Peter, Wang, Lin, Rabinowitz, Joshua D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284419/ https://www.ncbi.nlm.nih.gov/pubmed/34799699 http://dx.doi.org/10.1038/s42255-021-00465-w

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