Dissecting protein tyrosine phosphatase signaling by engineered chemogenetic control of its activity

Protein tyrosine phosphatases (PTPases) are critical mediators of dynamic cell signaling. A tool capable of identifying transient signaling events downstream of PTPases is essential to understand phosphatase function on a physiological time scale. We report a broadly applicable protein engineering m...

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Detalles Bibliográficos
Autores principales: Fauser, Jordan, Huyot, Vincent, Matsche, Jacob, Szynal, Barbara N., Alexeev, Yuri, Kota, Pradeep, Karginov, Andrei V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Tools
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284425/
https://www.ncbi.nlm.nih.gov/pubmed/35829702
http://dx.doi.org/10.1083/jcb.202111066

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