In vivo validation of the switch antibody concept: SPECT/CT imaging of the anti-CD137 switch antibody Sta-MB shows high uptake in tumors but low uptake in normal organs in human CD137 knock-in mice

CD137 is an attractive target for cancer immunotherapy, but its expression in normal tissues induces some adverse effects in patients receiving CD137-targeted therapy. To overcome this issue, we developed a switch antibody, STA551, that binds to CD137 only under high ATP concentrations around cells....

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Detalles Bibliográficos
Autores principales: Sugyo, Aya, Tsuji, Atsushi B, Sudo, Hitomi, Narita, Yoshinori, Taniguchi, Kenji, Nemoto, Takayuki, Isomura, Fumihisa, Awaya, Norihiro, Kamata-Sakurai, Mika, Higashi, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284450/
https://www.ncbi.nlm.nih.gov/pubmed/35820360
http://dx.doi.org/10.1016/j.tranon.2022.101481

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