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A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient
Remdesivir is a direct-acting inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase that is used to treat severe COVID-19 infections. We report a patient with severe COVID-19 pneumonia who experienced palpitations and syncope two days after starting remdesivir therapy. The QTc interval was prolonged...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284529/ https://www.ncbi.nlm.nih.gov/pubmed/35855472 http://dx.doi.org/10.1016/j.idcr.2022.e01572 |
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author | Harbi, Shmeylan Al AlFaifi, Mashael Al-Dorzi, Hasan M. Aljuhani, Ohoud Alenazi, Abeer A. Alalawi, Mai Sulaiman, Khalid Al |
author_facet | Harbi, Shmeylan Al AlFaifi, Mashael Al-Dorzi, Hasan M. Aljuhani, Ohoud Alenazi, Abeer A. Alalawi, Mai Sulaiman, Khalid Al |
author_sort | Harbi, Shmeylan Al |
collection | PubMed |
description | Remdesivir is a direct-acting inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase that is used to treat severe COVID-19 infections. We report a patient with severe COVID-19 pneumonia who experienced palpitations and syncope two days after starting remdesivir therapy. The QTc interval was prolonged on the Electrocardiogram (ECG) without any significant electrolyte abnormalities or concomitant use of medications with QTc prolongation. Although the cardiac side effects of remdesivir therapy have been well documented, the link between remdesivir therapy and QTc interval prolongation in patients with severe COVID-19 has only been observed in a few cases. Because this arrhythmia has the potential to result in sudden cardiac death, practitioners should be aware of the QTc interval prolongation associated with remdesivir therapy. |
format | Online Article Text |
id | pubmed-9284529 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-92845292022-07-15 A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient Harbi, Shmeylan Al AlFaifi, Mashael Al-Dorzi, Hasan M. Aljuhani, Ohoud Alenazi, Abeer A. Alalawi, Mai Sulaiman, Khalid Al IDCases Case Report Remdesivir is a direct-acting inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase that is used to treat severe COVID-19 infections. We report a patient with severe COVID-19 pneumonia who experienced palpitations and syncope two days after starting remdesivir therapy. The QTc interval was prolonged on the Electrocardiogram (ECG) without any significant electrolyte abnormalities or concomitant use of medications with QTc prolongation. Although the cardiac side effects of remdesivir therapy have been well documented, the link between remdesivir therapy and QTc interval prolongation in patients with severe COVID-19 has only been observed in a few cases. Because this arrhythmia has the potential to result in sudden cardiac death, practitioners should be aware of the QTc interval prolongation associated with remdesivir therapy. Elsevier 2022-07-15 /pmc/articles/PMC9284529/ /pubmed/35855472 http://dx.doi.org/10.1016/j.idcr.2022.e01572 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Harbi, Shmeylan Al AlFaifi, Mashael Al-Dorzi, Hasan M. Aljuhani, Ohoud Alenazi, Abeer A. Alalawi, Mai Sulaiman, Khalid Al A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient |
title | A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient |
title_full | A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient |
title_fullStr | A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient |
title_full_unstemmed | A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient |
title_short | A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient |
title_sort | case report on the association between qtc prolongation and remdesivir therapy in a critically ill patient |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284529/ https://www.ncbi.nlm.nih.gov/pubmed/35855472 http://dx.doi.org/10.1016/j.idcr.2022.e01572 |
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