Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization

[Image: see text] α-Synuclein (α-Syn) is an intrinsically disordered protein which self-assembles into highly organized β-sheet structures that accumulate in plaques in brains of Parkinson’s disease patients. Oxidative stress influences α-Syn structure and self-assembly; however, the basis for this...

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Detalles Bibliográficos
Autores principales: Sahin, Cagla, Østerlund, Eva Christina, Österlund, Nicklas, Costeira-Paulo, Joana, Pedersen, Jannik Nedergaard, Christiansen, Gunna, Nielsen, Janni, Grønnemose, Anne Louise, Amstrup, Søren Kirk, Tiwari, Manish K., Rao, R. Shyama Prasad, Bjerrum, Morten Jannik, Ilag, Leopold L., Davies, Michael J., Marklund, Erik G., Pedersen, Jan Skov, Landreh, Michael, Møller, Ian Max, Jørgensen, Thomas J. D., Otzen, Daniel Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284551/
https://www.ncbi.nlm.nih.gov/pubmed/35749730
http://dx.doi.org/10.1021/jacs.2c03607

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