Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

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Immunization with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike elicits diverse antibodies, but it is unclear if any of the antibodies can neutralize broadly against other beta-coronaviruses. Here, we report antibody WS6 from a mouse immunized with mRNA encoding the SARS-CoV-2 s...

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Detalles Bibliográficos
Autores principales: Shi, Wei, Wang, Lingshu, Zhou, Tongqing, Sastry, Mallika, Yang, Eun Sung, Zhang, Yi, Chen, Man, Chen, Xuejun, Choe, Misook, Creanga, Adrian, Leung, Kwan, Olia, Adam S., Pegu, Amarendra, Rawi, Reda, Schön, Arne, Shen, Chen-Hsiang, Stancofski, Erik-Stephane D., Talana, Chloe Adrienna, Teng, I-Ting, Wang, Shuishu, Corbett, Kizzmekia S., Tsybovsky, Yaroslav, Mascola, John R., Kwong, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284671/
https://www.ncbi.nlm.nih.gov/pubmed/35841885
http://dx.doi.org/10.1016/j.str.2022.06.004
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