METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner

BACKGROUND: METTL3 is the core catalytic enzyme in m6A and is involved in a variety of cardiovascular diseases. However, whether and how METTL3 plays a role during angiotensin II (Ang-II)-induced myocardial hypertrophy is still unknown. METHODS: Neonatal rat cardiomyocytes (NRCMs) and C57BL/6J mice...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Rui, Qu, Yangyang, Ji, Zhenjun, Hao, Chunshu, Su, Yamin, Yao, Yuyu, Zuo, Wenjie, Chen, Xi, Yang, Mingming, Ma, Genshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284900/
https://www.ncbi.nlm.nih.gov/pubmed/35836108
http://dx.doi.org/10.1186/s11658-022-00349-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284900/
https://www.ncbi.nlm.nih.gov/pubmed/35836108
http://dx.doi.org/10.1186/s11658-022-00349-1

Ejemplares similares