Cargando…

METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner

BACKGROUND: METTL3 is the core catalytic enzyme in m6A and is involved in a variety of cardiovascular diseases. However, whether and how METTL3 plays a role during angiotensin II (Ang-II)-induced myocardial hypertrophy is still unknown. METHODS: Neonatal rat cardiomyocytes (NRCMs) and C57BL/6J mice...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Rui, Qu, Yangyang, Ji, Zhenjun, Hao, Chunshu, Su, Yamin, Yao, Yuyu, Zuo, Wenjie, Chen, Xi, Yang, Mingming, Ma, Genshan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284900/ https://www.ncbi.nlm.nih.gov/pubmed/35836108 http://dx.doi.org/10.1186/s11658-022-00349-1

Ejemplares similares

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner
por: Han, Jie, et al.
Publicado: (2019)

METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner
por: Pan, Xiaoping, et al.
Publicado: (2021)

Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy
por: Zhang, Rui, et al.
Publicado: (2022)

Accuracy of triggering receptor expressed on myeloid cells 1 in diagnosis and prognosis of acute myocardial infarction: a prospective cohort study
por: Ji, Zhenjun, et al.
Publicado: (2021)

Upregulation of Biomarker Limd1 Was Correlated with Immune Infiltration in Doxorubicin-Related Cardiotoxicity
por: Zhang, Rui, et al.
Publicado: (2023)

Microrna-221 and Microrna-222 Modulate Differentiation and Maturation of Skeletal Muscle Cells
por: Cardinali, Beatrice, et al.
Publicado: (2009)

METTL3 promotes colorectal cancer metastasis by promoting the maturation of pri-microRNA-196b
por: Huang, Lanlan, et al.
Publicado: (2022)

Inflammatory activation and immune cell infiltration are main biological characteristics of SARS-CoV-2 infected myocardium
por: Zhang, Rui, et al.
Publicado: (2022)

METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer
por: Sun, Kangyue, et al.
Publicado: (2023)

The Neutrophil-to-Lymphocyte Ratio Is an Important Indicator Predicting In-Hospital Death in AMI Patients
por: Ji, Zhenjun, et al.
Publicado: (2021)

The Association Between Quantitative Flow Ratio and Intravascular Imaging-defined Vulnerable Plaque Characteristics in Patients With Stable Angina and Non-ST-segment Elevation Acute Coronary Syndrome
por: Zuo, Wenjie, et al.
Publicado: (2021)

Role of MicroRNAs-221/222 in Digestive Systems
por: Matsuzaki, Juntaro, et al.
Publicado: (2015)

METTL3 promotes the initiation and metastasis of ovarian cancer by inhibiting CCNG2 expression via promoting the maturation of pri-microRNA-1246
por: Bi, Xuehan, et al.
Publicado: (2021)

Overexpression of primary microRNA 221/222 in acute myeloid leukemia
por: Rommer, Anna, et al.
Publicado: (2013)

Human miR-221/222 in Physiological and Atherosclerotic Vascular Remodeling
por: Chistiakov, Dmitry A., et al.
Publicado: (2015)

Gastric Carcinogenesis in the miR-222/221 Transgenic Mouse Model
por: Choi, Boram, et al.
Publicado: (2017)

Role of miR-221/222 in Tumor Development and the Underlying Mechanism
por: Song, Qian, et al.
Publicado: (2019)

Influence of miR-221/222 on cardiomyocyte calcium handling and function
por: Knyrim, Maria, et al.
Publicado: (2021)

Overexpression of GATA4 enhances the antiapoptotic effect of exosomes secreted from cardiac colony-forming unit fibroblasts via miRNA221-mediated targeting of the PTEN/PI3K/AKT signaling pathway
por: Hao, Chunshu, et al.
Publicado: (2020)

miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells
por: Quintavalle, Cristina, et al.
Publicado: (2013)

Genistein Promotes Skeletal Muscle Regeneration by Regulating miR-221/222
por: Shen, Linyuan, et al.
Publicado: (2022)

Macrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction
por: Zuo, Wenjie, et al.
Publicado: (2023)

miR‐221‐3p targets Ang‐2 to inhibit the transformation of HCMECs to tip cells
por: Yang, Peng, et al.
Publicado: (2023)

miRNA-221 and miRNA-222 synergistically function to promote vascular calcification
por: Mackenzie, N C W, et al.
Publicado: (2014)

Targeting hepatic miR-221/222 for therapeutic intervention of nonalcoholic steatohepatitis in mice
por: Jiang, Xiuli, et al.
Publicado: (2018)

MicroRNA 221/222 cluster kicks out Timp-3 to inflame the liver
por: Menghini, Rossella, et al.
Publicado: (2018)

Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases
por: Song, Jialin, et al.
Publicado: (2017)

Effect of ligustilide on Ang II-induced hypertrophy in cardiomyocytes and the potential mechanisms
por: LU, QUN, et al.
Publicado: (2014)

Bulges control pri-miRNA processing in a position and strand-dependent manner
por: Li, Shaohua, et al.
Publicado: (2020)

MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma
por: Zhang, Chun-Zhi, et al.
Publicado: (2010)

In Vitro and in Vivo Anti-tumor Activity of miR-221/222 Inhibitors in Multiple Myeloma
por: Di Martino, Maria Teresa, et al.
Publicado: (2013)

miR-221/222 induces pancreatic cancer progression through the regulation of matrix metalloproteinases
por: Xu, Qinhong, et al.
Publicado: (2015)

Identification of targets of miRNA-221 and miRNA-222 in fulvestrant-resistant breast cancer
por: Liu, Pengfei, et al.
Publicado: (2016)

Androgen receptor-mediated downregulation of microRNA-221 and -222 in castration-resistant prostate cancer
por: Gui, Bin, et al.
Publicado: (2017)

Propofol Ameliorates Microglia Activation by Targeting MicroRNA-221/222-IRF2 Axis
por: Xiao, Xi, et al.
Publicado: (2021)

Novel Therapeutic Effects of Pterosin B on Ang II-Induced Cardiomyocyte Hypertrophy
por: Lee, Chang Youn, et al.
Publicado: (2020)

Association between serum adipsin and plaque vulnerability determined by optical coherence tomography in patients with coronary artery disease
por: Sun, Renhua, et al.
Publicado: (2021)

Overexpression of miR-221 in sudden death with cardiac hypertrophy patients
por: Kakimoto, Yu, et al.
Publicado: (2018)

The Inhibition of the Highly Expressed Mir-221 and Mir-222 Impairs the Growth of Prostate Carcinoma Xenografts in Mice
por: Mercatelli, Neri, et al.
Publicado: (2008)

High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma
por: Zhang, Chunzhi, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_vc9r3puegvq5lj6bg1ajoleod7