m(6)A-modified circRNAs: detections, mechanisms, and prospects in cancers

Circular RNAs (circRNAs) have become a research hotspot in recent years with their universality, diversity, stability, conservativeness, and spatiotemporal specificity. N(6)-methyladenosine (m(6)A), the most abundant modification in the eukaryotic cells, is engaged in the pathophysiological processe...

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Autores principales: Qin, Shiyi, Zhang, Qi, Xu, Yanhua, Ma, Shuo, Wang, Tianyi, Huang, Yuejiao, Ju, Shaoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284916/
https://www.ncbi.nlm.nih.gov/pubmed/35836125
http://dx.doi.org/10.1186/s10020-022-00505-5
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author Qin, Shiyi
Zhang, Qi
Xu, Yanhua
Ma, Shuo
Wang, Tianyi
Huang, Yuejiao
Ju, Shaoqing
author_facet Qin, Shiyi
Zhang, Qi
Xu, Yanhua
Ma, Shuo
Wang, Tianyi
Huang, Yuejiao
Ju, Shaoqing
author_sort Qin, Shiyi
collection PubMed
description Circular RNAs (circRNAs) have become a research hotspot in recent years with their universality, diversity, stability, conservativeness, and spatiotemporal specificity. N(6)-methyladenosine (m(6)A), the most abundant modification in the eukaryotic cells, is engaged in the pathophysiological processes of various diseases. An increasing amount of evidence has suggested that m(6)A modification is common in circRNAs and is associated with their biological functions. This review summarizes the effects of m(6)A modification on circRNAs and their regulation mechanisms in cancers, providing some suggestions of m(6)A-modified circRNAs in cancer therapy.
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spelling pubmed-92849162022-07-16 m(6)A-modified circRNAs: detections, mechanisms, and prospects in cancers Qin, Shiyi Zhang, Qi Xu, Yanhua Ma, Shuo Wang, Tianyi Huang, Yuejiao Ju, Shaoqing Mol Med Review Circular RNAs (circRNAs) have become a research hotspot in recent years with their universality, diversity, stability, conservativeness, and spatiotemporal specificity. N(6)-methyladenosine (m(6)A), the most abundant modification in the eukaryotic cells, is engaged in the pathophysiological processes of various diseases. An increasing amount of evidence has suggested that m(6)A modification is common in circRNAs and is associated with their biological functions. This review summarizes the effects of m(6)A modification on circRNAs and their regulation mechanisms in cancers, providing some suggestions of m(6)A-modified circRNAs in cancer therapy. BioMed Central 2022-07-14 /pmc/articles/PMC9284916/ /pubmed/35836125 http://dx.doi.org/10.1186/s10020-022-00505-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Qin, Shiyi
Zhang, Qi
Xu, Yanhua
Ma, Shuo
Wang, Tianyi
Huang, Yuejiao
Ju, Shaoqing
m(6)A-modified circRNAs: detections, mechanisms, and prospects in cancers
title m(6)A-modified circRNAs: detections, mechanisms, and prospects in cancers
title_full m(6)A-modified circRNAs: detections, mechanisms, and prospects in cancers
title_fullStr m(6)A-modified circRNAs: detections, mechanisms, and prospects in cancers
title_full_unstemmed m(6)A-modified circRNAs: detections, mechanisms, and prospects in cancers
title_short m(6)A-modified circRNAs: detections, mechanisms, and prospects in cancers
title_sort m(6)a-modified circrnas: detections, mechanisms, and prospects in cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284916/
https://www.ncbi.nlm.nih.gov/pubmed/35836125
http://dx.doi.org/10.1186/s10020-022-00505-5
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