Severe Hyperprolactinemia during Lurasidone Treatment in a 16-year Old Girl with Schizophrenia – A Case Report

BACKGROUND: Increase of serum prolactin is a common adverse effect to antipsychotic medication, potentially leading to galactorrhea, menstrual cycle disturbances or sexual adverse effects. Lurasidone is commonly associated with a low risk of prolactin change. OBJECTIVE: To describe a case of severe hyperprolactinemia in a 16-year old female with schizophrenia. METHOD: Case report. RESULTS: We saw a severe and sustained prolactin increase during treatment with lurasidone. CONCLUSIONS: Although lurasidone is usually considered not to increase prolactin, some patients may experience this adverse effect. As related subjective consequences may be falsely attributed to the disease or as direct effects of the antipsycotic agent, serum prolactin measurements should be made prior to and during antipsychotic treatment regardless of medication choice.