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Predicting ablation zones with multislice volumetric 2-D magnetic resonance thermal imaging

BACKGROUND: High-intensity focused ultrasound (HIFU) serves as a noninvasive stereotactic system for the ablation of brain metastases; however, treatments are limited to simple geometries and energy delivery is limited by the high acoustic attenuation of the calvarium. Minimally-invasive magnetic re...

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Detalles Bibliográficos
Autores principales: Campwala, Zahabiya, Szewczyk, Benjamin, Maietta, Teresa, Trowbridge, Rachel, Tarasek, Matthew, Bhushan, Chitresh, Fiveland, Eric, Ghoshal, Goutam, Heffter, Tamas, Gandomi, Katie, Carvalho, Paulo Alberto, Nycz, Christopher, Jeannotte, Erin, Staudt, Michael, Nalwalk, Julia, Hellman, Abigail, Zhao, Zhanyue, Burdette, E. Clif, Fischer, Gregory, Yeo, Desmond, Pilitsis, Julie G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284994/
https://www.ncbi.nlm.nih.gov/pubmed/34148489
http://dx.doi.org/10.1080/02656736.2021.1936215
Descripción
Sumario:BACKGROUND: High-intensity focused ultrasound (HIFU) serves as a noninvasive stereotactic system for the ablation of brain metastases; however, treatments are limited to simple geometries and energy delivery is limited by the high acoustic attenuation of the calvarium. Minimally-invasive magnetic resonance-guided robotically-assisted (MRgRA) needle-based therapeutic ultrasound (NBTU) using multislice volumetric 2-D magnetic resonance thermal imaging (MRTI) overcomes these limitations and has potential to produce less collateral tissue damage than current methods. OBJECTIVE: To correlate multislice volumetric 2-D MRTI volumes with histologically confirmed regions of tissue damage in MRgRA NBTU. METHODS: Seven swine underwent a total of 8 frontal MRgRA NBTU lesions. MRTI ablation volumes were compared to histologic tissue damage on brain sections stained with 2,3,5-triphenyltetrazolium chloride (TTC). Bland-Altman analyses and correlation trends were used to compare MRTI and TTC ablation volumes. RESULTS: Data from the initial and third swine’s ablations were excluded due to sub-optimal tissue staining. For the remaining ablations (n = 6), the limits of agreement between the MRTI and histologic volumes ranged from −0.149 cm(3) to 0.252 cm(3) with a mean difference of 0.052 ±0.042 cm(3) (11.1%). There was a high correlation between the MRTI and histology volumes (r(2) = 0.831) with a strong linear relationship (r = 0.868). CONCLUSION: We used a volumetric MRTI technique to accurately track thermal changes during MRgRA NBTU in preparation for human trials. Improved volumetric coverage with MRTI enhanced our delivery of therapy and has far-reaching implications for focused ultrasound in the broader clinical setting.