Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice

Microglia are strongly implicated in the development and progression of Alzheimer’s disease (AD), yet their impact on pathology and lifespan remains unclear. Here we utilize a CSF1R hypomorphic mouse to generate a model of AD that genetically lacks microglia. The resulting microglial-deficient mice...

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Detalles Bibliográficos
Autores principales: Shabestari, Sepideh Kiani, Morabito, Samuel, Danhash, Emma Pascal, McQuade, Amanda, Sanchez, Jessica Ramirez, Miyoshi, Emily, Chadarevian, Jean Paul, Claes, Christel, Coburn, Morgan Alexandra, Hasselmann, Jonathan, Hidalgo, Jorge, Tran, Kayla Nhi, Martini, Alessandra C., Rothermich, Winston Chang, Pascual, Jesse, Head, Elizabeth, Hume, David A., Pridans, Clare, Davtyan, Hayk, Swarup, Vivek, Blurton-Jones, Mathew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285116/
https://www.ncbi.nlm.nih.gov/pubmed/35705056
http://dx.doi.org/10.1016/j.celrep.2022.110961

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