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Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers
BACKGROUND: Helicobacter pylori infection is a well‐established risk factor for gastric cancer and has been linked to other gastrointestinal diseases, including pancreatic and biliary tract cancers; however, the relevance of enterohepatic non‐H. pylori helicobacters to the pathophysiology of these d...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285378/ https://www.ncbi.nlm.nih.gov/pubmed/35005807 http://dx.doi.org/10.1111/hel.12866 |
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author | Osaki, Takako Lin, Yingsong Sasahira, Naoki Ueno, Makoto Yonezawa, Hideo Hojo, Fuhito Okuda, Masumi Matsuyama, Masato Sasaki, Takashi Kobayashi, Satoshi Tezuka, Shun Tanaka, Kei Dan, Naoaki Kuruma, Sawako Egawa, Naoto Kamiya, Shigeru Kikuchi, Shogo |
author_facet | Osaki, Takako Lin, Yingsong Sasahira, Naoki Ueno, Makoto Yonezawa, Hideo Hojo, Fuhito Okuda, Masumi Matsuyama, Masato Sasaki, Takashi Kobayashi, Satoshi Tezuka, Shun Tanaka, Kei Dan, Naoaki Kuruma, Sawako Egawa, Naoto Kamiya, Shigeru Kikuchi, Shogo |
author_sort | Osaki, Takako |
collection | PubMed |
description | BACKGROUND: Helicobacter pylori infection is a well‐established risk factor for gastric cancer and has been linked to other gastrointestinal diseases, including pancreatic and biliary tract cancers; however, the relevance of enterohepatic non‐H. pylori helicobacters to the pathophysiology of these diseases remains unclear. MATERIALS AND METHODS: We estimated the prevalence of two enterohepatic non‐H. pylori helicobacters (Helicobacter hepaticus and Helicobacter bilis) in the framework of a hospital‐based case‐control study involving 121 patients with biliary tract cancer, pancreatic cancer, or other gastrointestinal diseases. Bile and blood samples were collected from the patients undergoing endoscopic retrograde cholangiopancreatography. The presence of H. bilis, H. hepaticus, and other Helicobacter spp. was examined using bacterial culture, PCR‐based detection, and serological tests. RESULTS: Culture of Helicobacter spp. from biliary brush samples was unsuccessful. Approximately 13.0% (15/115) of the bile samples collected from patients with a variety of gastrointestinal cancers, including pancreatic and biliary tract cancers, tested positive for one of the enterohepatic non‐H. pylori helicobacter species as determined by PCR. Specifically, H. bilis and H. hepaticus DNA were detected in 11 and 4 bile samples, respectively. Approximately 20%–40% of the patients tested positive for serum non‐H. pylori helicobacter IgG antibodies. The seroprevalence of H. bilis and H. hepaticus in the patients without evidence of H. pylori infection appeared to be higher in the pancreatic cancer group than in the control group. CONCLUSION: Our findings suggest a role for Helicobacter spp., especially H. bilis and H. hepaticus, in the etiology of pancreatic and biliary tract cancers. |
format | Online Article Text |
id | pubmed-9285378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92853782022-07-15 Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers Osaki, Takako Lin, Yingsong Sasahira, Naoki Ueno, Makoto Yonezawa, Hideo Hojo, Fuhito Okuda, Masumi Matsuyama, Masato Sasaki, Takashi Kobayashi, Satoshi Tezuka, Shun Tanaka, Kei Dan, Naoaki Kuruma, Sawako Egawa, Naoto Kamiya, Shigeru Kikuchi, Shogo Helicobacter Original Articles BACKGROUND: Helicobacter pylori infection is a well‐established risk factor for gastric cancer and has been linked to other gastrointestinal diseases, including pancreatic and biliary tract cancers; however, the relevance of enterohepatic non‐H. pylori helicobacters to the pathophysiology of these diseases remains unclear. MATERIALS AND METHODS: We estimated the prevalence of two enterohepatic non‐H. pylori helicobacters (Helicobacter hepaticus and Helicobacter bilis) in the framework of a hospital‐based case‐control study involving 121 patients with biliary tract cancer, pancreatic cancer, or other gastrointestinal diseases. Bile and blood samples were collected from the patients undergoing endoscopic retrograde cholangiopancreatography. The presence of H. bilis, H. hepaticus, and other Helicobacter spp. was examined using bacterial culture, PCR‐based detection, and serological tests. RESULTS: Culture of Helicobacter spp. from biliary brush samples was unsuccessful. Approximately 13.0% (15/115) of the bile samples collected from patients with a variety of gastrointestinal cancers, including pancreatic and biliary tract cancers, tested positive for one of the enterohepatic non‐H. pylori helicobacter species as determined by PCR. Specifically, H. bilis and H. hepaticus DNA were detected in 11 and 4 bile samples, respectively. Approximately 20%–40% of the patients tested positive for serum non‐H. pylori helicobacter IgG antibodies. The seroprevalence of H. bilis and H. hepaticus in the patients without evidence of H. pylori infection appeared to be higher in the pancreatic cancer group than in the control group. CONCLUSION: Our findings suggest a role for Helicobacter spp., especially H. bilis and H. hepaticus, in the etiology of pancreatic and biliary tract cancers. John Wiley and Sons Inc. 2022-01-10 2022-02 /pmc/articles/PMC9285378/ /pubmed/35005807 http://dx.doi.org/10.1111/hel.12866 Text en © 2022 The Authors. Helicobacter published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Osaki, Takako Lin, Yingsong Sasahira, Naoki Ueno, Makoto Yonezawa, Hideo Hojo, Fuhito Okuda, Masumi Matsuyama, Masato Sasaki, Takashi Kobayashi, Satoshi Tezuka, Shun Tanaka, Kei Dan, Naoaki Kuruma, Sawako Egawa, Naoto Kamiya, Shigeru Kikuchi, Shogo Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers |
title | Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers |
title_full | Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers |
title_fullStr | Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers |
title_full_unstemmed | Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers |
title_short | Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers |
title_sort | prevalence estimates of helicobacter species infection in pancreatic and biliary tract cancers |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285378/ https://www.ncbi.nlm.nih.gov/pubmed/35005807 http://dx.doi.org/10.1111/hel.12866 |
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