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Efficacy of cryotherapy for plantar warts: A systematic review and meta‐analysis

Recent systematic reviews of plantar warts continue to consider cryotherapy as one of the treatments of choice, but this method appears to have lower cure rates than alternative treatments. A systematic review using meta‐analyses of the efficacy of cryotherapy in plantar warts treatment was performe...

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Autores principales: García‐Oreja, Sara, Álvaro‐Afonso, Francisco Javier, Tardáguila‐García, Aroa, López‐Moral, Mateo, García‐Madrid, Marta, Lázaro‐Martínez, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285476/
https://www.ncbi.nlm.nih.gov/pubmed/35365922
http://dx.doi.org/10.1111/dth.15480
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author García‐Oreja, Sara
Álvaro‐Afonso, Francisco Javier
Tardáguila‐García, Aroa
López‐Moral, Mateo
García‐Madrid, Marta
Lázaro‐Martínez, José Luis
author_facet García‐Oreja, Sara
Álvaro‐Afonso, Francisco Javier
Tardáguila‐García, Aroa
López‐Moral, Mateo
García‐Madrid, Marta
Lázaro‐Martínez, José Luis
author_sort García‐Oreja, Sara
collection PubMed
description Recent systematic reviews of plantar warts continue to consider cryotherapy as one of the treatments of choice, but this method appears to have lower cure rates than alternative treatments. A systematic review using meta‐analyses of the efficacy of cryotherapy in plantar warts treatment was performed. Systematic electronic searches were conducted. The primary endpoint was complete clearance of plantar warts. Risk‐of‐bias assessment was based on Cochrane Handbook recommendations. Meta‐analyses used Review Manager v5.4.1 software. Cryotherapy appears to have lower cure rates than other treatments (odds ratio [OR] 0.31, 95% confidence interval [CI] 0.12–0.78) with substantial heterogeneity (I (2) = 80%). A second subgroup analysis had low heterogeneity (I (2) = 28.2%). Subgroup analysis showed that plantar wart cure rates were significantly lower with cryotherapy compared to the physical treatment group (OR 0.05, 95% CI 0.01–0.49) with substantial heterogeneity (I (2) = 79%), and antiviral, chemotherapy, and retinoid group (OR 0.30, 95% CI 0.14–0.66) without heterogeneity (I (2) = 0%). Intralesional versus spray‐on cryotherapy appears to be more effective (OR 0.21, 95% CI 0.09–0.48). No difference in efficacy between two rounds of 10‐s and four rounds of 5‐s freeze–thaw cycles in cryotherapy was found. Evidence of the superiority of antivirals and chemotherapy over cryotherapy in the treatment of plantar warts was found. However, no evidence supports the superiority or inferiority of cryotherapy compared to other treatments.
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spelling pubmed-92854762022-07-18 Efficacy of cryotherapy for plantar warts: A systematic review and meta‐analysis García‐Oreja, Sara Álvaro‐Afonso, Francisco Javier Tardáguila‐García, Aroa López‐Moral, Mateo García‐Madrid, Marta Lázaro‐Martínez, José Luis Dermatol Ther Original Articles Recent systematic reviews of plantar warts continue to consider cryotherapy as one of the treatments of choice, but this method appears to have lower cure rates than alternative treatments. A systematic review using meta‐analyses of the efficacy of cryotherapy in plantar warts treatment was performed. Systematic electronic searches were conducted. The primary endpoint was complete clearance of plantar warts. Risk‐of‐bias assessment was based on Cochrane Handbook recommendations. Meta‐analyses used Review Manager v5.4.1 software. Cryotherapy appears to have lower cure rates than other treatments (odds ratio [OR] 0.31, 95% confidence interval [CI] 0.12–0.78) with substantial heterogeneity (I (2) = 80%). A second subgroup analysis had low heterogeneity (I (2) = 28.2%). Subgroup analysis showed that plantar wart cure rates were significantly lower with cryotherapy compared to the physical treatment group (OR 0.05, 95% CI 0.01–0.49) with substantial heterogeneity (I (2) = 79%), and antiviral, chemotherapy, and retinoid group (OR 0.30, 95% CI 0.14–0.66) without heterogeneity (I (2) = 0%). Intralesional versus spray‐on cryotherapy appears to be more effective (OR 0.21, 95% CI 0.09–0.48). No difference in efficacy between two rounds of 10‐s and four rounds of 5‐s freeze–thaw cycles in cryotherapy was found. Evidence of the superiority of antivirals and chemotherapy over cryotherapy in the treatment of plantar warts was found. However, no evidence supports the superiority or inferiority of cryotherapy compared to other treatments. John Wiley & Sons, Inc. 2022-04-06 2022-06 /pmc/articles/PMC9285476/ /pubmed/35365922 http://dx.doi.org/10.1111/dth.15480 Text en © 2022 The Authors. Dermatologic Therapy published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
García‐Oreja, Sara
Álvaro‐Afonso, Francisco Javier
Tardáguila‐García, Aroa
López‐Moral, Mateo
García‐Madrid, Marta
Lázaro‐Martínez, José Luis
Efficacy of cryotherapy for plantar warts: A systematic review and meta‐analysis
title Efficacy of cryotherapy for plantar warts: A systematic review and meta‐analysis
title_full Efficacy of cryotherapy for plantar warts: A systematic review and meta‐analysis
title_fullStr Efficacy of cryotherapy for plantar warts: A systematic review and meta‐analysis
title_full_unstemmed Efficacy of cryotherapy for plantar warts: A systematic review and meta‐analysis
title_short Efficacy of cryotherapy for plantar warts: A systematic review and meta‐analysis
title_sort efficacy of cryotherapy for plantar warts: a systematic review and meta‐analysis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285476/
https://www.ncbi.nlm.nih.gov/pubmed/35365922
http://dx.doi.org/10.1111/dth.15480
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