Hookworm infections: Reappraising the evidence for a role of neutrophils in light of NETosis

In Hookworm infection, neutrophils have long had the image of the villain, being recruited to the site of larval migration because of damage but participating themselves in tissue injury. With recent developments in neutrophil biology, there is an increasing body of evidence for the role of neutroph...

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Detalles Bibliográficos
Autores principales: Doolan, Rory, Bouchery, Tiffany
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Invited Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285577/
https://www.ncbi.nlm.nih.gov/pubmed/35124825
http://dx.doi.org/10.1111/pim.12911
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author Doolan, Rory
Bouchery, Tiffany
author_facet Doolan, Rory
Bouchery, Tiffany
author_sort Doolan, Rory
collection PubMed
description In Hookworm infection, neutrophils have long had the image of the villain, being recruited to the site of larval migration because of damage but participating themselves in tissue injury. With recent developments in neutrophil biology, there is an increasing body of evidence for the role of neutrophils as effector cells in hookworm immunity. In particular, their ability to release extracellular traps, or neutrophil extracellular traps (NETs), confer neutrophils a larvicidal activity. Here, we review recent evidence in this nascent field and discuss the avenue for future research on NETs/hookworm interactions.
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spelling pubmed-92855772022-07-18 Hookworm infections: Reappraising the evidence for a role of neutrophils in light of NETosis Doolan, Rory Bouchery, Tiffany Parasite Immunol Invited Reviews In Hookworm infection, neutrophils have long had the image of the villain, being recruited to the site of larval migration because of damage but participating themselves in tissue injury. With recent developments in neutrophil biology, there is an increasing body of evidence for the role of neutrophils as effector cells in hookworm immunity. In particular, their ability to release extracellular traps, or neutrophil extracellular traps (NETs), confer neutrophils a larvicidal activity. Here, we review recent evidence in this nascent field and discuss the avenue for future research on NETs/hookworm interactions. John Wiley and Sons Inc. 2022-03-07 2022-06 /pmc/articles/PMC9285577/ /pubmed/35124825 http://dx.doi.org/10.1111/pim.12911 Text en © 2022 The Authors. Parasite Immunology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Invited Reviews
Doolan, Rory
Bouchery, Tiffany
Hookworm infections: Reappraising the evidence for a role of neutrophils in light of NETosis
title Hookworm infections: Reappraising the evidence for a role of neutrophils in light of NETosis
title_full Hookworm infections: Reappraising the evidence for a role of neutrophils in light of NETosis
title_fullStr Hookworm infections: Reappraising the evidence for a role of neutrophils in light of NETosis
title_full_unstemmed Hookworm infections: Reappraising the evidence for a role of neutrophils in light of NETosis
title_short Hookworm infections: Reappraising the evidence for a role of neutrophils in light of NETosis
title_sort hookworm infections: reappraising the evidence for a role of neutrophils in light of netosis
topic Invited Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285577/
https://www.ncbi.nlm.nih.gov/pubmed/35124825
http://dx.doi.org/10.1111/pim.12911
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