lncRNA HITT Inhibits Lactate Production by Repressing PKM2 Oligomerization to Reduce Tumor Growth and Macrophage Polarization

Lactic acid acidifies the tumor microenvironment and promotes multiple critical oncogenic processes, including immune evasion. Pyruvate kinase M2 (PKM2) is a dominant form of pyruvate kinase (PK) expressed in cancers that plays essential roles in metabolic reprograming and lactate production, render...

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Detalles Bibliográficos
Autores principales: Zhao, Kunming, Wang, Xingwen, Zhao, Dong, Lin, Qingyu, Zhang, Yi, Hu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285634/
https://www.ncbi.nlm.nih.gov/pubmed/35909936
http://dx.doi.org/10.34133/2022/9854904

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