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NF-κB Regulation by Gut Microbiota Decides Homeostasis or Disease Outcome During Ageing
Human beings and their indigenous microbial communities have coexisted for centuries, which led to the development of co-evolutionary mechanisms of communication and cooperation. Such communication machineries are governed by sophisticated multi-step feedback loops, which typically begin with the re...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285657/ https://www.ncbi.nlm.nih.gov/pubmed/35846362 http://dx.doi.org/10.3389/fcell.2022.874940 |
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author | Zhang, Shuning Paul, Soumyajeet Kundu, Parag |
author_facet | Zhang, Shuning Paul, Soumyajeet Kundu, Parag |
author_sort | Zhang, Shuning |
collection | PubMed |
description | Human beings and their indigenous microbial communities have coexisted for centuries, which led to the development of co-evolutionary mechanisms of communication and cooperation. Such communication machineries are governed by sophisticated multi-step feedback loops, which typically begin with the recognition of microbes by pattern recognition receptors (PRRs), followed by a host transcriptional response leading to the release of effector molecules. Our gastrointestinal tract being the main platform for this interaction, a variety of host intestinal cells tightly regulate these loops to establish tolerance towards the microbial communities of the gut and maintain homeostasis. The transcription factor, nuclear factor kappa B (NF-κB) is an integral component of such a communication apparatus, which plays a critical role in determining the state of homeostasis or inflammation associated with dysbiosis in the host. Here we outline the crucial role of NF-κB in host response to microbial cues in the context of ageing and associated diseases. |
format | Online Article Text |
id | pubmed-9285657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92856572022-07-16 NF-κB Regulation by Gut Microbiota Decides Homeostasis or Disease Outcome During Ageing Zhang, Shuning Paul, Soumyajeet Kundu, Parag Front Cell Dev Biol Cell and Developmental Biology Human beings and their indigenous microbial communities have coexisted for centuries, which led to the development of co-evolutionary mechanisms of communication and cooperation. Such communication machineries are governed by sophisticated multi-step feedback loops, which typically begin with the recognition of microbes by pattern recognition receptors (PRRs), followed by a host transcriptional response leading to the release of effector molecules. Our gastrointestinal tract being the main platform for this interaction, a variety of host intestinal cells tightly regulate these loops to establish tolerance towards the microbial communities of the gut and maintain homeostasis. The transcription factor, nuclear factor kappa B (NF-κB) is an integral component of such a communication apparatus, which plays a critical role in determining the state of homeostasis or inflammation associated with dysbiosis in the host. Here we outline the crucial role of NF-κB in host response to microbial cues in the context of ageing and associated diseases. Frontiers Media S.A. 2022-07-01 /pmc/articles/PMC9285657/ /pubmed/35846362 http://dx.doi.org/10.3389/fcell.2022.874940 Text en Copyright © 2022 Zhang, Paul and Kundu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Zhang, Shuning Paul, Soumyajeet Kundu, Parag NF-κB Regulation by Gut Microbiota Decides Homeostasis or Disease Outcome During Ageing |
title | NF-κB Regulation by Gut Microbiota Decides Homeostasis or Disease Outcome During Ageing |
title_full | NF-κB Regulation by Gut Microbiota Decides Homeostasis or Disease Outcome During Ageing |
title_fullStr | NF-κB Regulation by Gut Microbiota Decides Homeostasis or Disease Outcome During Ageing |
title_full_unstemmed | NF-κB Regulation by Gut Microbiota Decides Homeostasis or Disease Outcome During Ageing |
title_short | NF-κB Regulation by Gut Microbiota Decides Homeostasis or Disease Outcome During Ageing |
title_sort | nf-κb regulation by gut microbiota decides homeostasis or disease outcome during ageing |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285657/ https://www.ncbi.nlm.nih.gov/pubmed/35846362 http://dx.doi.org/10.3389/fcell.2022.874940 |
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