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Pyroptosis: A Novel Intervention Target in the Progression of Osteoarthritis

Osteoarthritis (OA) is one of the most common chronic joint diseases and is gradually becoming the main cause of disability and joint pain in the elderly worldwide. Pyroptosis is a regulated programmed cell death triggered by inflammasomes. It leads to cell swelling, lysis, and bioactive molecule se...

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Autores principales: Chang, Xingyu, Kang, Yuchen, Yang, Yuxuan, Chen, Yajie, Shen, Yanyu, Jiang, Chenjun, Shen, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285853/
https://www.ncbi.nlm.nih.gov/pubmed/35845090
http://dx.doi.org/10.2147/JIR.S368501
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author Chang, Xingyu
Kang, Yuchen
Yang, Yuxuan
Chen, Yajie
Shen, Yanyu
Jiang, Chenjun
Shen, Yi
author_facet Chang, Xingyu
Kang, Yuchen
Yang, Yuxuan
Chen, Yajie
Shen, Yanyu
Jiang, Chenjun
Shen, Yi
author_sort Chang, Xingyu
collection PubMed
description Osteoarthritis (OA) is one of the most common chronic joint diseases and is gradually becoming the main cause of disability and joint pain in the elderly worldwide. Pyroptosis is a regulated programmed cell death triggered by inflammasomes. It leads to cell swelling, lysis, and bioactive molecule secretion. Studies found that the damaged chondrocytes in OA joints had morphological characteristics of pyroptosis, and the cytokines associated with pyroptosis in synovial fluid increased, indicating that pyroptosis may have certain impacts on the pathological progression of OA. This review briefly summarizes the molecular mechanisms of pyroptosis and the epidemiology and pathogenesis of OA. Furthermore, we discussed the role of pyroptosis in articular cartilage and synovium during OA and reviewed the progress of pyroptosis-related molecules in the targeted therapy of OA joints, hoping to provide feasible directions for the diversified treatment of OA.
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spelling pubmed-92858532022-07-16 Pyroptosis: A Novel Intervention Target in the Progression of Osteoarthritis Chang, Xingyu Kang, Yuchen Yang, Yuxuan Chen, Yajie Shen, Yanyu Jiang, Chenjun Shen, Yi J Inflamm Res Review Osteoarthritis (OA) is one of the most common chronic joint diseases and is gradually becoming the main cause of disability and joint pain in the elderly worldwide. Pyroptosis is a regulated programmed cell death triggered by inflammasomes. It leads to cell swelling, lysis, and bioactive molecule secretion. Studies found that the damaged chondrocytes in OA joints had morphological characteristics of pyroptosis, and the cytokines associated with pyroptosis in synovial fluid increased, indicating that pyroptosis may have certain impacts on the pathological progression of OA. This review briefly summarizes the molecular mechanisms of pyroptosis and the epidemiology and pathogenesis of OA. Furthermore, we discussed the role of pyroptosis in articular cartilage and synovium during OA and reviewed the progress of pyroptosis-related molecules in the targeted therapy of OA joints, hoping to provide feasible directions for the diversified treatment of OA. Dove 2022-07-11 /pmc/articles/PMC9285853/ /pubmed/35845090 http://dx.doi.org/10.2147/JIR.S368501 Text en © 2022 Chang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Chang, Xingyu
Kang, Yuchen
Yang, Yuxuan
Chen, Yajie
Shen, Yanyu
Jiang, Chenjun
Shen, Yi
Pyroptosis: A Novel Intervention Target in the Progression of Osteoarthritis
title Pyroptosis: A Novel Intervention Target in the Progression of Osteoarthritis
title_full Pyroptosis: A Novel Intervention Target in the Progression of Osteoarthritis
title_fullStr Pyroptosis: A Novel Intervention Target in the Progression of Osteoarthritis
title_full_unstemmed Pyroptosis: A Novel Intervention Target in the Progression of Osteoarthritis
title_short Pyroptosis: A Novel Intervention Target in the Progression of Osteoarthritis
title_sort pyroptosis: a novel intervention target in the progression of osteoarthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285853/
https://www.ncbi.nlm.nih.gov/pubmed/35845090
http://dx.doi.org/10.2147/JIR.S368501
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