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Mediator recruits the cohesin loader Scc2 to RNA Pol II-transcribed genes and promotes sister chromatid cohesion

The ring-like cohesin complex plays an essential role in chromosome segregation, organization, and double-strand break repair through its ability to bring two DNA double helices together. Scc2 (NIPBL in humans) together with Scc4 functions as the loader of cohesin onto chromosomes. Chromatin adapter...

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Detalles Bibliográficos
Autores principales:	Mattingly, Mark, Seidel, Chris, Muñoz, Sofía, Hao, Yan, Zhang, Ying, Wen, Zhihui, Florens, Laurence, Uhlmann, Frank, Gerton, Jennifer L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286023/ https://www.ncbi.nlm.nih.gov/pubmed/35654035 http://dx.doi.org/10.1016/j.cub.2022.05.019

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