Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis

Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. NEC is characterized by intestinal tissue inflammation and necrosis. The intestinal barrier is altered in NEC, which potentially contributes to its pathogenesis by promoting intestinal bacterial translo...

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Autores principales: Managlia, Elizabeth, Yan, Xiaocai, De Plaen, Isabelle G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286028/
https://www.ncbi.nlm.nih.gov/pubmed/35846894
http://dx.doi.org/10.5005/jp-journals-11002-0003
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author Managlia, Elizabeth
Yan, Xiaocai
De Plaen, Isabelle G
author_facet Managlia, Elizabeth
Yan, Xiaocai
De Plaen, Isabelle G
author_sort Managlia, Elizabeth
collection PubMed
description Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. NEC is characterized by intestinal tissue inflammation and necrosis. The intestinal barrier is altered in NEC, which potentially contributes to its pathogenesis by promoting intestinal bacterial translocation and stimulating the inflammatory response. In premature infants, many components of the intestinal barrier are immature. This article reviews the different components of the intestinal barrier and how their immaturity contributes to intestinal barrier dysfunction and NEC.
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spelling pubmed-92860282022-07-15 Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis Managlia, Elizabeth Yan, Xiaocai De Plaen, Isabelle G Newborn (Clarksville) Article Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. NEC is characterized by intestinal tissue inflammation and necrosis. The intestinal barrier is altered in NEC, which potentially contributes to its pathogenesis by promoting intestinal bacterial translocation and stimulating the inflammatory response. In premature infants, many components of the intestinal barrier are immature. This article reviews the different components of the intestinal barrier and how their immaturity contributes to intestinal barrier dysfunction and NEC. 2022 2022-03-31 /pmc/articles/PMC9286028/ /pubmed/35846894 http://dx.doi.org/10.5005/jp-journals-11002-0003 Text en https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated.
spellingShingle Article
Managlia, Elizabeth
Yan, Xiaocai
De Plaen, Isabelle G
Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis
title Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis
title_full Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis
title_fullStr Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis
title_full_unstemmed Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis
title_short Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis
title_sort intestinal epithelial barrier function and necrotizing enterocolitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286028/
https://www.ncbi.nlm.nih.gov/pubmed/35846894
http://dx.doi.org/10.5005/jp-journals-11002-0003
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