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Importance of the Cyclic Cystine Knot Structural Motif for Immunosuppressive Effects of Cyclotides

[Image: see text] The cyclotide T20K inhibits the proliferation of human immune cells and is currently in clinical trials for multiple sclerosis. Here, we provide novel functional data and mechanistic insights into structure–activity relationships of T20K. Analogs with partial or complete reduction...

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Detalles Bibliográficos
Autores principales:	Hellinger, Roland, Muratspahić, Edin, Devi, Seema, Koehbach, Johannes, Vasileva, Mina, Harvey, Peta J., Craik, David J., Gründemann, Carsten, Gruber, Christian W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286316/ https://www.ncbi.nlm.nih.gov/pubmed/34592097 http://dx.doi.org/10.1021/acschembio.1c00524

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