ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells

27-Hydroxycholesterol (27-HC) is the most abundant oxysterol that increases the risk of breast cancer progression. However, little is known about epigenetic regulation of 27-HC metabolism and its role in breast tumor initiation. Using genetic mouse mammary tumor and human breast cancer models, we sh...

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Detalles Bibliográficos
Autores principales: Luo, Maowu, Bao, Lei, Chen, Yan, Xue, Yuanyuan, Wang, Yong, Zhang, Bo, Wang, Chenliang, Corley, Chase D., McDonald, Jeffrey G., Kumar, Ashwani, Xing, Chao, Fang, Yisheng, Nelson, Erik R., Wang, Jennifer E., Wang, Yingfei, Luo, Weibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286501/
https://www.ncbi.nlm.nih.gov/pubmed/35857506
http://dx.doi.org/10.1126/sciadv.abn5295

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