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Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review
Recently there has been increasing interest and debate on the use of tranexamic acid (TXA), an antifibrinolytic drug, in both traumatic and non‐traumatic intracranial hemorrhage. In this review we aim to discuss recent investigations looking at TXA in traumatic brain injury (TBI) and different categ...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286528/ https://www.ncbi.nlm.nih.gov/pubmed/35859856 http://dx.doi.org/10.1002/emp2.12777 |
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author | Jakowenko, Nicholas D. Kopp, Brian J. Erstad, Brian L. |
author_facet | Jakowenko, Nicholas D. Kopp, Brian J. Erstad, Brian L. |
author_sort | Jakowenko, Nicholas D. |
collection | PubMed |
description | Recently there has been increasing interest and debate on the use of tranexamic acid (TXA), an antifibrinolytic drug, in both traumatic and non‐traumatic intracranial hemorrhage. In this review we aim to discuss recent investigations looking at TXA in traumatic brain injury (TBI) and different categories of spontaneous intracranial hemorrhage. We also discuss differences between setting (hospital vs pre‐hospital), dosing and timing strategies, and other logistical challenges surrounding optimal use of TXA for isolated intracranial hemorrhage. Last, we hope to provide guidance for clinicians when considering the use of TXA in a patient with traumatic or non‐traumatic intracranial hemorrhage based on appraisal of the available literature as well as some potential ideas for future research in this area. |
format | Online Article Text |
id | pubmed-9286528 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92865282022-07-19 Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review Jakowenko, Nicholas D. Kopp, Brian J. Erstad, Brian L. J Am Coll Emerg Physicians Open Trauma Recently there has been increasing interest and debate on the use of tranexamic acid (TXA), an antifibrinolytic drug, in both traumatic and non‐traumatic intracranial hemorrhage. In this review we aim to discuss recent investigations looking at TXA in traumatic brain injury (TBI) and different categories of spontaneous intracranial hemorrhage. We also discuss differences between setting (hospital vs pre‐hospital), dosing and timing strategies, and other logistical challenges surrounding optimal use of TXA for isolated intracranial hemorrhage. Last, we hope to provide guidance for clinicians when considering the use of TXA in a patient with traumatic or non‐traumatic intracranial hemorrhage based on appraisal of the available literature as well as some potential ideas for future research in this area. John Wiley and Sons Inc. 2022-07-15 /pmc/articles/PMC9286528/ /pubmed/35859856 http://dx.doi.org/10.1002/emp2.12777 Text en © 2022 The Authors. JACEP Open published by Wiley Periodicals LLC on behalf of American College of Emergency Physicians. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Trauma Jakowenko, Nicholas D. Kopp, Brian J. Erstad, Brian L. Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review |
title | Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review |
title_full | Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review |
title_fullStr | Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review |
title_full_unstemmed | Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review |
title_short | Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review |
title_sort | appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: a narrative review |
topic | Trauma |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286528/ https://www.ncbi.nlm.nih.gov/pubmed/35859856 http://dx.doi.org/10.1002/emp2.12777 |
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