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The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review
It has been demonstrated that lactoferrin (LF) plays a role in host defence, but evidence on its potential antiviral property from clinical studies is fragmented. Our systematic review aimed at identifying the effects of orally administered LF against virus infections. The systematic search was cond...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286571/ https://www.ncbi.nlm.nih.gov/pubmed/34133812 http://dx.doi.org/10.1002/rmv.2261 |
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author | Sinopoli, Alessandra Isonne, Claudia Santoro, Maria Mercedes Baccolini, Valentina |
author_facet | Sinopoli, Alessandra Isonne, Claudia Santoro, Maria Mercedes Baccolini, Valentina |
author_sort | Sinopoli, Alessandra |
collection | PubMed |
description | It has been demonstrated that lactoferrin (LF) plays a role in host defence, but evidence on its potential antiviral property from clinical studies is fragmented. Our systematic review aimed at identifying the effects of orally administered LF against virus infections. The systematic search was conducted on PubMed, Scopus, Web of Science, BioRxiv.org and ClinicalTrials.gov from database inception to 7th January 2021. Eligible articles investigated any virus family and provided data on the effects of orally administered LF of any origin in the prevention and/or management of confirmed viral infections in people of any age. A narrative synthesis of the results was performed. Quality was assessed with the Cochrane Risk‐Of‐Bias and ROBINS‐1 tools. A total of 27 records were included, nine of which were registered protocols. We found data on Flaviviridae (n = 10), Retroviridae (n = 3), Coronaviridae (n = 2), Reoviridae (n = 2) and Caliciviridae (n = 1). Most published trials were at high risk of bias. The findings were heterogeneous across and within viral families regarding virological, immunological and biological response, with no clear conclusion. Some weak but positive results were reported about decrease of symptom severity and duration, or reduction in viral loads. Despite high tolerability, the effects of LF as oral supplement are still inconsistent, both in preventing and managing viral infections. Small sample sizes, variety in recruitment and treatment protocols, and low study quality may have contributed to such heterogeneity. Better‐designed studies are needed to further investigate its potential benefits against viral infections, including SARS‐CoV‐2. |
format | Online Article Text |
id | pubmed-9286571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92865712022-07-19 The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review Sinopoli, Alessandra Isonne, Claudia Santoro, Maria Mercedes Baccolini, Valentina Rev Med Virol Review It has been demonstrated that lactoferrin (LF) plays a role in host defence, but evidence on its potential antiviral property from clinical studies is fragmented. Our systematic review aimed at identifying the effects of orally administered LF against virus infections. The systematic search was conducted on PubMed, Scopus, Web of Science, BioRxiv.org and ClinicalTrials.gov from database inception to 7th January 2021. Eligible articles investigated any virus family and provided data on the effects of orally administered LF of any origin in the prevention and/or management of confirmed viral infections in people of any age. A narrative synthesis of the results was performed. Quality was assessed with the Cochrane Risk‐Of‐Bias and ROBINS‐1 tools. A total of 27 records were included, nine of which were registered protocols. We found data on Flaviviridae (n = 10), Retroviridae (n = 3), Coronaviridae (n = 2), Reoviridae (n = 2) and Caliciviridae (n = 1). Most published trials were at high risk of bias. The findings were heterogeneous across and within viral families regarding virological, immunological and biological response, with no clear conclusion. Some weak but positive results were reported about decrease of symptom severity and duration, or reduction in viral loads. Despite high tolerability, the effects of LF as oral supplement are still inconsistent, both in preventing and managing viral infections. Small sample sizes, variety in recruitment and treatment protocols, and low study quality may have contributed to such heterogeneity. Better‐designed studies are needed to further investigate its potential benefits against viral infections, including SARS‐CoV‐2. John Wiley and Sons Inc. 2021-05-28 2022-01 /pmc/articles/PMC9286571/ /pubmed/34133812 http://dx.doi.org/10.1002/rmv.2261 Text en © 2021 The Authors. Reviews in Medical Virology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Sinopoli, Alessandra Isonne, Claudia Santoro, Maria Mercedes Baccolini, Valentina The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review |
title | The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review |
title_full | The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review |
title_fullStr | The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review |
title_full_unstemmed | The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review |
title_short | The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review |
title_sort | effects of orally administered lactoferrin in the prevention and management of viral infections: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286571/ https://www.ncbi.nlm.nih.gov/pubmed/34133812 http://dx.doi.org/10.1002/rmv.2261 |
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