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Analysis of fouling and breakthrough of process related impurities during depth filtration using confocal microscopy
Titer improvement has driven process intensification in mAb manufacture. However, this has come with the drawback of high cell densities and associated process related impurities such as cell debris, host cell protein (HCP), and DNA. This affects the capacity of depth filters and can lead to carryov...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286597/ https://www.ncbi.nlm.nih.gov/pubmed/35037432 http://dx.doi.org/10.1002/btpr.3233 |