The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments

Obesity is associated with hypothalamic–pituitary–testicular axis dysregulation in males. Here, we summarize recent evidence derived from clinical trials and studies in preclinical animal models regarding the role of androgen receptor (AR) signaling in the pathophysiology of males with obesity. We a...

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Detalles Bibliográficos
Autores principales: Venkatesh, Varun S., Grossmann, Mathis, Zajac, Jeffrey D., Davey, Rachel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Etiology and Pathophysiology/Obesity Treatment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286619/
https://www.ncbi.nlm.nih.gov/pubmed/35083843
http://dx.doi.org/10.1111/obr.13429
Descripción
Sumario:Obesity is associated with hypothalamic–pituitary–testicular axis dysregulation in males. Here, we summarize recent evidence derived from clinical trials and studies in preclinical animal models regarding the role of androgen receptor (AR) signaling in the pathophysiology of males with obesity. We also discuss therapeutic strategies targeting the AR for the treatment of obesity and their limitations and provide insight into the future research necessary to advance this field.

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