The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments

Obesity is associated with hypothalamic–pituitary–testicular axis dysregulation in males. Here, we summarize recent evidence derived from clinical trials and studies in preclinical animal models regarding the role of androgen receptor (AR) signaling in the pathophysiology of males with obesity. We a...

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Autores principales: Venkatesh, Varun S., Grossmann, Mathis, Zajac, Jeffrey D., Davey, Rachel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Etiology and Pathophysiology/Obesity Treatment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286619/
https://www.ncbi.nlm.nih.gov/pubmed/35083843
http://dx.doi.org/10.1111/obr.13429
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author Venkatesh, Varun S.
Grossmann, Mathis
Zajac, Jeffrey D.
Davey, Rachel A.
author_facet Venkatesh, Varun S.
Grossmann, Mathis
Zajac, Jeffrey D.
Davey, Rachel A.
author_sort Venkatesh, Varun S.
collection PubMed
description Obesity is associated with hypothalamic–pituitary–testicular axis dysregulation in males. Here, we summarize recent evidence derived from clinical trials and studies in preclinical animal models regarding the role of androgen receptor (AR) signaling in the pathophysiology of males with obesity. We also discuss therapeutic strategies targeting the AR for the treatment of obesity and their limitations and provide insight into the future research necessary to advance this field.
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spelling pubmed-92866192022-07-19 The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments Venkatesh, Varun S. Grossmann, Mathis Zajac, Jeffrey D. Davey, Rachel A. Obes Rev Etiology and Pathophysiology/Obesity Treatment Obesity is associated with hypothalamic–pituitary–testicular axis dysregulation in males. Here, we summarize recent evidence derived from clinical trials and studies in preclinical animal models regarding the role of androgen receptor (AR) signaling in the pathophysiology of males with obesity. We also discuss therapeutic strategies targeting the AR for the treatment of obesity and their limitations and provide insight into the future research necessary to advance this field. John Wiley and Sons Inc. 2022-01-27 2022-06 /pmc/articles/PMC9286619/ /pubmed/35083843 http://dx.doi.org/10.1111/obr.13429 Text en © 2022 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Etiology and Pathophysiology/Obesity Treatment
Venkatesh, Varun S.
Grossmann, Mathis
Zajac, Jeffrey D.
Davey, Rachel A.
The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments
title The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments
title_full The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments
title_fullStr The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments
title_full_unstemmed The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments
title_short The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments
title_sort role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments
topic Etiology and Pathophysiology/Obesity Treatment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286619/
https://www.ncbi.nlm.nih.gov/pubmed/35083843
http://dx.doi.org/10.1111/obr.13429
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