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Investigating the moderators and mediators of an effective sleep intervention in the Prevention of Overweight in Infancy (POI) randomized controlled trial: Exploratory analyses

The Prevention of Overweight in Infancy (POI) sleep intervention halved obesity risk at 2 years of age. However, the intervention mechanisms are unclear. Consequently, the objective of the current work was to use exploratory analyses to investigate potential moderators and mediators of the sleep int...

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Autores principales: Fangupo, Louise, Haszard, Jillian, Galland, Barbara, Taylor, Barry, Heath, Anne‐Louise, Healey, Dione, Meredith‐Jones, Kim, Sayers, Rachel, Hatch, Burt, Taylor, Rachael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286685/
https://www.ncbi.nlm.nih.gov/pubmed/35297224
http://dx.doi.org/10.1111/cob.12516
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author Fangupo, Louise
Haszard, Jillian
Galland, Barbara
Taylor, Barry
Heath, Anne‐Louise
Healey, Dione
Meredith‐Jones, Kim
Sayers, Rachel
Hatch, Burt
Taylor, Rachael
author_facet Fangupo, Louise
Haszard, Jillian
Galland, Barbara
Taylor, Barry
Heath, Anne‐Louise
Healey, Dione
Meredith‐Jones, Kim
Sayers, Rachel
Hatch, Burt
Taylor, Rachael
author_sort Fangupo, Louise
collection PubMed
description The Prevention of Overweight in Infancy (POI) sleep intervention halved obesity risk at 2 years of age. However, the intervention mechanisms are unclear. Consequently, the objective of the current work was to use exploratory analyses to investigate potential moderators and mediators of the sleep intervention on obesity outcomes at age 2 years. Data were collected between 2009 and 2012. The effect of demographic and study design variables on body mass index z‐score (BMI z‐score) and obesity was compared in moderator subgroups at 2 years of age (n = 683, 85%). Mediating effects of child and parent–household variables assessed whether the sleep intervention resulted in meaningful changes in the mediating variable (defined as changes which were statistically significant [p < .05] or where the effect size was ≥0.15 SD), followed by assessing relationships with obesity outcomes. The sleep intervention appeared most effective in children in higher deprivation areas (effect on BMI z‐score −0.25 [−0.53, 0.04], effect on obesity odds ratio [OR] 0.43 [0.16, 1.13]), and with mothers of non‐European, non‐Māori ethnicity (effect on BMI z‐score −0.27 [−0.73, 0.20], effect on obesity OR 0.13 [95% confidence interval 0.01, 1.11]). This suggested moderation by deprivation and ethnicity. Aspects of sleep improved meaningfully in children after intervention but did not significantly relate to obesity outcomes, and other outcomes were not meaningfully affected by the sleep intervention. Thus, mediation was not indicated. Overall, the POI sleep intervention improved obesity outcomes at 2 years, and the current work identified some potential moderators, but no mediators.
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spelling pubmed-92866852022-07-19 Investigating the moderators and mediators of an effective sleep intervention in the Prevention of Overweight in Infancy (POI) randomized controlled trial: Exploratory analyses Fangupo, Louise Haszard, Jillian Galland, Barbara Taylor, Barry Heath, Anne‐Louise Healey, Dione Meredith‐Jones, Kim Sayers, Rachel Hatch, Burt Taylor, Rachael Clin Obes Original Research Articles The Prevention of Overweight in Infancy (POI) sleep intervention halved obesity risk at 2 years of age. However, the intervention mechanisms are unclear. Consequently, the objective of the current work was to use exploratory analyses to investigate potential moderators and mediators of the sleep intervention on obesity outcomes at age 2 years. Data were collected between 2009 and 2012. The effect of demographic and study design variables on body mass index z‐score (BMI z‐score) and obesity was compared in moderator subgroups at 2 years of age (n = 683, 85%). Mediating effects of child and parent–household variables assessed whether the sleep intervention resulted in meaningful changes in the mediating variable (defined as changes which were statistically significant [p < .05] or where the effect size was ≥0.15 SD), followed by assessing relationships with obesity outcomes. The sleep intervention appeared most effective in children in higher deprivation areas (effect on BMI z‐score −0.25 [−0.53, 0.04], effect on obesity odds ratio [OR] 0.43 [0.16, 1.13]), and with mothers of non‐European, non‐Māori ethnicity (effect on BMI z‐score −0.27 [−0.73, 0.20], effect on obesity OR 0.13 [95% confidence interval 0.01, 1.11]). This suggested moderation by deprivation and ethnicity. Aspects of sleep improved meaningfully in children after intervention but did not significantly relate to obesity outcomes, and other outcomes were not meaningfully affected by the sleep intervention. Thus, mediation was not indicated. Overall, the POI sleep intervention improved obesity outcomes at 2 years, and the current work identified some potential moderators, but no mediators. Blackwell Publishing Ltd 2022-03-16 2022-06 /pmc/articles/PMC9286685/ /pubmed/35297224 http://dx.doi.org/10.1111/cob.12516 Text en © 2022 The Authors. Clinical Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Articles
Fangupo, Louise
Haszard, Jillian
Galland, Barbara
Taylor, Barry
Heath, Anne‐Louise
Healey, Dione
Meredith‐Jones, Kim
Sayers, Rachel
Hatch, Burt
Taylor, Rachael
Investigating the moderators and mediators of an effective sleep intervention in the Prevention of Overweight in Infancy (POI) randomized controlled trial: Exploratory analyses
title Investigating the moderators and mediators of an effective sleep intervention in the Prevention of Overweight in Infancy (POI) randomized controlled trial: Exploratory analyses
title_full Investigating the moderators and mediators of an effective sleep intervention in the Prevention of Overweight in Infancy (POI) randomized controlled trial: Exploratory analyses
title_fullStr Investigating the moderators and mediators of an effective sleep intervention in the Prevention of Overweight in Infancy (POI) randomized controlled trial: Exploratory analyses
title_full_unstemmed Investigating the moderators and mediators of an effective sleep intervention in the Prevention of Overweight in Infancy (POI) randomized controlled trial: Exploratory analyses
title_short Investigating the moderators and mediators of an effective sleep intervention in the Prevention of Overweight in Infancy (POI) randomized controlled trial: Exploratory analyses
title_sort investigating the moderators and mediators of an effective sleep intervention in the prevention of overweight in infancy (poi) randomized controlled trial: exploratory analyses
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286685/
https://www.ncbi.nlm.nih.gov/pubmed/35297224
http://dx.doi.org/10.1111/cob.12516
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