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Association between Blood Donation and Malignant and Benign Tumour Risk: A Population-Based Study of 3.4 Million Participants in China

This study aims to identify the relationship between blood donation and malignant and benign tumour hospitalization risk. The cohort study was constructed in Shaanxi, China, to include blood donors and match nonblood donors one-to-one by gender, age, and county of residence. The study compared the h...

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Autores principales: Su, Shu, Ma, Ting, Sun, Yang, Guo, Lingxia, Su, Xiaodong, Wang, Wenhua, Xie, Xinxin, Wang, Liqin, Xing, Lili, Zhang, Leilei, He, Shiyi, Yang, Jiangcun, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286895/
https://www.ncbi.nlm.nih.gov/pubmed/35847363
http://dx.doi.org/10.1155/2022/7647431
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author Su, Shu
Ma, Ting
Sun, Yang
Guo, Lingxia
Su, Xiaodong
Wang, Wenhua
Xie, Xinxin
Wang, Liqin
Xing, Lili
Zhang, Leilei
He, Shiyi
Yang, Jiangcun
Zhang, Lei
author_facet Su, Shu
Ma, Ting
Sun, Yang
Guo, Lingxia
Su, Xiaodong
Wang, Wenhua
Xie, Xinxin
Wang, Liqin
Xing, Lili
Zhang, Leilei
He, Shiyi
Yang, Jiangcun
Zhang, Lei
author_sort Su, Shu
collection PubMed
description This study aims to identify the relationship between blood donation and malignant and benign tumour hospitalization risk. The cohort study was constructed in Shaanxi, China, to include blood donors and match nonblood donors one-to-one by gender, age, and county of residence. The study compared the hospitalization records of two groups from 2012 to 2018. A log-binomial regression model was used to estimate the relative risk (RR) of tumour risk between donors and nonblood donors among different age groups. A total of 1,625,599 donors were recruited (including 968,823 males) and compared with the matched nonblood donor group. Significantly lower risk of malignancy in males was found among donors (adjusted RR: 0.82, 95% CI: 0.75–0.92). Lower risks for specific types of tumours among donors were observed, including liver (0.42, [0.28–0.67]), lung (0.74, [0.59–0.87]), lymphoma (0.75, [0.62–0.85]), and oesophagus (0.55, [0.41–0.72]). However, the risk of brain cancer was higher among male donors (RR 1.19 [1.06–1.29]). Among female donors, lower risk of liver (0.57, [0.42–0.79]) and oesophagus malignancy (0.73, [0.62–0.88]) was observed. For benign tumours, male donors have a lower risk of benign skin tumour (0.79, [0.62–0.94]) and hemangioma and lymphangioma (0.75, [0.51–0.89]), while female donors have a lower risk in hemangioma and lymphangioma (0.65, [0.44–0.83]). We also found that the risk decreased with age among donors in the prevalence of tumours compared to that in nonblood donors (p < 0.05). Blood donation appears to be significantly associated with various tumour risks among both males and females. Overall, the risk of tumours decreased more substantially with age in blood donors compared with nonblood donors. Further research is warranted to investigate the impact of ‘health donor effects' on these findings.
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spelling pubmed-92868952022-07-16 Association between Blood Donation and Malignant and Benign Tumour Risk: A Population-Based Study of 3.4 Million Participants in China Su, Shu Ma, Ting Sun, Yang Guo, Lingxia Su, Xiaodong Wang, Wenhua Xie, Xinxin Wang, Liqin Xing, Lili Zhang, Leilei He, Shiyi Yang, Jiangcun Zhang, Lei J Oncol Research Article This study aims to identify the relationship between blood donation and malignant and benign tumour hospitalization risk. The cohort study was constructed in Shaanxi, China, to include blood donors and match nonblood donors one-to-one by gender, age, and county of residence. The study compared the hospitalization records of two groups from 2012 to 2018. A log-binomial regression model was used to estimate the relative risk (RR) of tumour risk between donors and nonblood donors among different age groups. A total of 1,625,599 donors were recruited (including 968,823 males) and compared with the matched nonblood donor group. Significantly lower risk of malignancy in males was found among donors (adjusted RR: 0.82, 95% CI: 0.75–0.92). Lower risks for specific types of tumours among donors were observed, including liver (0.42, [0.28–0.67]), lung (0.74, [0.59–0.87]), lymphoma (0.75, [0.62–0.85]), and oesophagus (0.55, [0.41–0.72]). However, the risk of brain cancer was higher among male donors (RR 1.19 [1.06–1.29]). Among female donors, lower risk of liver (0.57, [0.42–0.79]) and oesophagus malignancy (0.73, [0.62–0.88]) was observed. For benign tumours, male donors have a lower risk of benign skin tumour (0.79, [0.62–0.94]) and hemangioma and lymphangioma (0.75, [0.51–0.89]), while female donors have a lower risk in hemangioma and lymphangioma (0.65, [0.44–0.83]). We also found that the risk decreased with age among donors in the prevalence of tumours compared to that in nonblood donors (p < 0.05). Blood donation appears to be significantly associated with various tumour risks among both males and females. Overall, the risk of tumours decreased more substantially with age in blood donors compared with nonblood donors. Further research is warranted to investigate the impact of ‘health donor effects' on these findings. Hindawi 2022-07-08 /pmc/articles/PMC9286895/ /pubmed/35847363 http://dx.doi.org/10.1155/2022/7647431 Text en Copyright © 2022 Shu Su et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Su, Shu
Ma, Ting
Sun, Yang
Guo, Lingxia
Su, Xiaodong
Wang, Wenhua
Xie, Xinxin
Wang, Liqin
Xing, Lili
Zhang, Leilei
He, Shiyi
Yang, Jiangcun
Zhang, Lei
Association between Blood Donation and Malignant and Benign Tumour Risk: A Population-Based Study of 3.4 Million Participants in China
title Association between Blood Donation and Malignant and Benign Tumour Risk: A Population-Based Study of 3.4 Million Participants in China
title_full Association between Blood Donation and Malignant and Benign Tumour Risk: A Population-Based Study of 3.4 Million Participants in China
title_fullStr Association between Blood Donation and Malignant and Benign Tumour Risk: A Population-Based Study of 3.4 Million Participants in China
title_full_unstemmed Association between Blood Donation and Malignant and Benign Tumour Risk: A Population-Based Study of 3.4 Million Participants in China
title_short Association between Blood Donation and Malignant and Benign Tumour Risk: A Population-Based Study of 3.4 Million Participants in China
title_sort association between blood donation and malignant and benign tumour risk: a population-based study of 3.4 million participants in china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286895/
https://www.ncbi.nlm.nih.gov/pubmed/35847363
http://dx.doi.org/10.1155/2022/7647431
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