Cargando…

Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments

Hepatic ischemia/reperfusion injury (IRI) is mainly characterized by high activation of immune inflammatory responses and metabolic responses. Understanding the molecular and metabolic mechanisms underlying development of hepatic IRI is critical for developing effective therapies for hepatic IRI. Re...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Fengqiang, Qiu, Xun, Wang, Kai, Shao, Chuxiao, Jin, Wenjian, Zhang, Zhen, Xu, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286916/
https://www.ncbi.nlm.nih.gov/pubmed/35855339
http://dx.doi.org/10.14336/AD.2022.0109
_version_ 1784748128370425856
author Gao, Fengqiang
Qiu, Xun
Wang, Kai
Shao, Chuxiao
Jin, Wenjian
Zhang, Zhen
Xu, Xiao
author_facet Gao, Fengqiang
Qiu, Xun
Wang, Kai
Shao, Chuxiao
Jin, Wenjian
Zhang, Zhen
Xu, Xiao
author_sort Gao, Fengqiang
collection PubMed
description Hepatic ischemia/reperfusion injury (IRI) is mainly characterized by high activation of immune inflammatory responses and metabolic responses. Understanding the molecular and metabolic mechanisms underlying development of hepatic IRI is critical for developing effective therapies for hepatic IRI. Recent advances in research have improved our understanding of the pathogenesis of IRI. During IRI, hepatocyte injury and inflammatory responses are mediated by crosstalk between the immune cells and metabolic components. This crosstalk can be targeted to treat or reverse hepatic IRI. Thus, a deep understanding of hepatic microenvironment, especially the immune and metabolic responses, can reveal new therapeutic opportunities for hepatic IRI. In this review, we describe important cells in the liver microenvironment (especially non-parenchymal cells) that regulate immune inflammatory responses. The role of metabolic components in the diagnosis and prevention of hepatic IRI are discussed. Furthermore, recent updated therapeutic strategies based on the hepatic microenvironment, including immune cells and metabolic components, are highlighted.
format Online
Article
Text
id pubmed-9286916
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher JKL International LLC
record_format MEDLINE/PubMed
spelling pubmed-92869162022-07-18 Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments Gao, Fengqiang Qiu, Xun Wang, Kai Shao, Chuxiao Jin, Wenjian Zhang, Zhen Xu, Xiao Aging Dis Review Hepatic ischemia/reperfusion injury (IRI) is mainly characterized by high activation of immune inflammatory responses and metabolic responses. Understanding the molecular and metabolic mechanisms underlying development of hepatic IRI is critical for developing effective therapies for hepatic IRI. Recent advances in research have improved our understanding of the pathogenesis of IRI. During IRI, hepatocyte injury and inflammatory responses are mediated by crosstalk between the immune cells and metabolic components. This crosstalk can be targeted to treat or reverse hepatic IRI. Thus, a deep understanding of hepatic microenvironment, especially the immune and metabolic responses, can reveal new therapeutic opportunities for hepatic IRI. In this review, we describe important cells in the liver microenvironment (especially non-parenchymal cells) that regulate immune inflammatory responses. The role of metabolic components in the diagnosis and prevention of hepatic IRI are discussed. Furthermore, recent updated therapeutic strategies based on the hepatic microenvironment, including immune cells and metabolic components, are highlighted. JKL International LLC 2022-07-11 /pmc/articles/PMC9286916/ /pubmed/35855339 http://dx.doi.org/10.14336/AD.2022.0109 Text en copyright: © 2022 Gao et al. https://creativecommons.org/licenses/by/2.0/this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
Gao, Fengqiang
Qiu, Xun
Wang, Kai
Shao, Chuxiao
Jin, Wenjian
Zhang, Zhen
Xu, Xiao
Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments
title Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments
title_full Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments
title_fullStr Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments
title_full_unstemmed Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments
title_short Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments
title_sort targeting the hepatic microenvironment to improve ischemia/reperfusion injury: new insights into the immune and metabolic compartments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286916/
https://www.ncbi.nlm.nih.gov/pubmed/35855339
http://dx.doi.org/10.14336/AD.2022.0109
work_keys_str_mv AT gaofengqiang targetingthehepaticmicroenvironmenttoimproveischemiareperfusioninjurynewinsightsintotheimmuneandmetaboliccompartments
AT qiuxun targetingthehepaticmicroenvironmenttoimproveischemiareperfusioninjurynewinsightsintotheimmuneandmetaboliccompartments
AT wangkai targetingthehepaticmicroenvironmenttoimproveischemiareperfusioninjurynewinsightsintotheimmuneandmetaboliccompartments
AT shaochuxiao targetingthehepaticmicroenvironmenttoimproveischemiareperfusioninjurynewinsightsintotheimmuneandmetaboliccompartments
AT jinwenjian targetingthehepaticmicroenvironmenttoimproveischemiareperfusioninjurynewinsightsintotheimmuneandmetaboliccompartments
AT zhangzhen targetingthehepaticmicroenvironmenttoimproveischemiareperfusioninjurynewinsightsintotheimmuneandmetaboliccompartments
AT xuxiao targetingthehepaticmicroenvironmenttoimproveischemiareperfusioninjurynewinsightsintotheimmuneandmetaboliccompartments