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Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments
Hepatic ischemia/reperfusion injury (IRI) is mainly characterized by high activation of immune inflammatory responses and metabolic responses. Understanding the molecular and metabolic mechanisms underlying development of hepatic IRI is critical for developing effective therapies for hepatic IRI. Re...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286916/ https://www.ncbi.nlm.nih.gov/pubmed/35855339 http://dx.doi.org/10.14336/AD.2022.0109 |
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author | Gao, Fengqiang Qiu, Xun Wang, Kai Shao, Chuxiao Jin, Wenjian Zhang, Zhen Xu, Xiao |
author_facet | Gao, Fengqiang Qiu, Xun Wang, Kai Shao, Chuxiao Jin, Wenjian Zhang, Zhen Xu, Xiao |
author_sort | Gao, Fengqiang |
collection | PubMed |
description | Hepatic ischemia/reperfusion injury (IRI) is mainly characterized by high activation of immune inflammatory responses and metabolic responses. Understanding the molecular and metabolic mechanisms underlying development of hepatic IRI is critical for developing effective therapies for hepatic IRI. Recent advances in research have improved our understanding of the pathogenesis of IRI. During IRI, hepatocyte injury and inflammatory responses are mediated by crosstalk between the immune cells and metabolic components. This crosstalk can be targeted to treat or reverse hepatic IRI. Thus, a deep understanding of hepatic microenvironment, especially the immune and metabolic responses, can reveal new therapeutic opportunities for hepatic IRI. In this review, we describe important cells in the liver microenvironment (especially non-parenchymal cells) that regulate immune inflammatory responses. The role of metabolic components in the diagnosis and prevention of hepatic IRI are discussed. Furthermore, recent updated therapeutic strategies based on the hepatic microenvironment, including immune cells and metabolic components, are highlighted. |
format | Online Article Text |
id | pubmed-9286916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | JKL International LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-92869162022-07-18 Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments Gao, Fengqiang Qiu, Xun Wang, Kai Shao, Chuxiao Jin, Wenjian Zhang, Zhen Xu, Xiao Aging Dis Review Hepatic ischemia/reperfusion injury (IRI) is mainly characterized by high activation of immune inflammatory responses and metabolic responses. Understanding the molecular and metabolic mechanisms underlying development of hepatic IRI is critical for developing effective therapies for hepatic IRI. Recent advances in research have improved our understanding of the pathogenesis of IRI. During IRI, hepatocyte injury and inflammatory responses are mediated by crosstalk between the immune cells and metabolic components. This crosstalk can be targeted to treat or reverse hepatic IRI. Thus, a deep understanding of hepatic microenvironment, especially the immune and metabolic responses, can reveal new therapeutic opportunities for hepatic IRI. In this review, we describe important cells in the liver microenvironment (especially non-parenchymal cells) that regulate immune inflammatory responses. The role of metabolic components in the diagnosis and prevention of hepatic IRI are discussed. Furthermore, recent updated therapeutic strategies based on the hepatic microenvironment, including immune cells and metabolic components, are highlighted. JKL International LLC 2022-07-11 /pmc/articles/PMC9286916/ /pubmed/35855339 http://dx.doi.org/10.14336/AD.2022.0109 Text en copyright: © 2022 Gao et al. https://creativecommons.org/licenses/by/2.0/this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Review Gao, Fengqiang Qiu, Xun Wang, Kai Shao, Chuxiao Jin, Wenjian Zhang, Zhen Xu, Xiao Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments |
title | Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments |
title_full | Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments |
title_fullStr | Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments |
title_full_unstemmed | Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments |
title_short | Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments |
title_sort | targeting the hepatic microenvironment to improve ischemia/reperfusion injury: new insights into the immune and metabolic compartments |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286916/ https://www.ncbi.nlm.nih.gov/pubmed/35855339 http://dx.doi.org/10.14336/AD.2022.0109 |
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