Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?

Acarbose can extend the life span of mice through a process involving the gut microbiota. Several factors affect the life span, including mitochondrial function, cellular senescence, telomere length, immune function, and expression of longevity-related genes. In this review, the effects of acarbose-...

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Detalles Bibliográficos
Autores principales: Wu, Baiyun, Yan, Jiai, Yang, Ju, Xia, Yanping, Li, Dan, Zhang, Feng, Cao, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286917/
https://www.ncbi.nlm.nih.gov/pubmed/35855337
http://dx.doi.org/10.14336/AD.2022.0117
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author Wu, Baiyun
Yan, Jiai
Yang, Ju
Xia, Yanping
Li, Dan
Zhang, Feng
Cao, Hong
author_facet Wu, Baiyun
Yan, Jiai
Yang, Ju
Xia, Yanping
Li, Dan
Zhang, Feng
Cao, Hong
author_sort Wu, Baiyun
collection PubMed
description Acarbose can extend the life span of mice through a process involving the gut microbiota. Several factors affect the life span, including mitochondrial function, cellular senescence, telomere length, immune function, and expression of longevity-related genes. In this review, the effects of acarbose-regulated gut microbiota on the life span-influencing factors have been discussed. In addition, a novel theoretical basis for improving our understanding of the mechanisms by which acarbose extends the life span of mice has been suggested.
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spelling pubmed-92869172022-07-18 Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota? Wu, Baiyun Yan, Jiai Yang, Ju Xia, Yanping Li, Dan Zhang, Feng Cao, Hong Aging Dis Commentary Acarbose can extend the life span of mice through a process involving the gut microbiota. Several factors affect the life span, including mitochondrial function, cellular senescence, telomere length, immune function, and expression of longevity-related genes. In this review, the effects of acarbose-regulated gut microbiota on the life span-influencing factors have been discussed. In addition, a novel theoretical basis for improving our understanding of the mechanisms by which acarbose extends the life span of mice has been suggested. JKL International LLC 2022-07-11 /pmc/articles/PMC9286917/ /pubmed/35855337 http://dx.doi.org/10.14336/AD.2022.0117 Text en copyright: © 2022 Wu et al. https://creativecommons.org/licenses/by/2.0/this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Commentary
Wu, Baiyun
Yan, Jiai
Yang, Ju
Xia, Yanping
Li, Dan
Zhang, Feng
Cao, Hong
Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?
title Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?
title_full Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?
title_fullStr Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?
title_full_unstemmed Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?
title_short Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?
title_sort extension of the life span by acarbose: is it mediated by the gut microbiota?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286917/
https://www.ncbi.nlm.nih.gov/pubmed/35855337
http://dx.doi.org/10.14336/AD.2022.0117
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