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Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease

Aging is a major global challenge, and there is growing demand for new strategies to address the burden of aging. The intensive search for antiaging agents has led to the discovery of a variety of drugs that promote the extension of healthspan and/or life. Metformin is a safe, effective, and globall...

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Autores principales: Cheng, Fang-Fang, Liu, Yan-Li, Du, Jang, Lin, Jun-Tang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286921/
https://www.ncbi.nlm.nih.gov/pubmed/35855344
http://dx.doi.org/10.14336/AD.2021.1213
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author Cheng, Fang-Fang
Liu, Yan-Li
Du, Jang
Lin, Jun-Tang
author_facet Cheng, Fang-Fang
Liu, Yan-Li
Du, Jang
Lin, Jun-Tang
author_sort Cheng, Fang-Fang
collection PubMed
description Aging is a major global challenge, and there is growing demand for new strategies to address the burden of aging. The intensive search for antiaging agents has led to the discovery of a variety of drugs that promote the extension of healthspan and/or life. Metformin is a safe, effective, and globally affordable antihyperglycemic agent that has gained much attention in recent years as a potential antiaging treatment. Metformin has been shown to significantly delay the onset of age-related diseases and increase lifespan in several model organisms. In this paper, we reviewed aging hallmarks and the role of metformin in countering these hallmarks. We examined the beneficial effects of metformin on several age-related diseases and the feasibility of metformin as an agent to extend lifespan and healthspan. Finally, we discussed new research directions to better understand the translational potential of metformin in humans.
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spelling pubmed-92869212022-07-18 Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease Cheng, Fang-Fang Liu, Yan-Li Du, Jang Lin, Jun-Tang Aging Dis Commentary Aging is a major global challenge, and there is growing demand for new strategies to address the burden of aging. The intensive search for antiaging agents has led to the discovery of a variety of drugs that promote the extension of healthspan and/or life. Metformin is a safe, effective, and globally affordable antihyperglycemic agent that has gained much attention in recent years as a potential antiaging treatment. Metformin has been shown to significantly delay the onset of age-related diseases and increase lifespan in several model organisms. In this paper, we reviewed aging hallmarks and the role of metformin in countering these hallmarks. We examined the beneficial effects of metformin on several age-related diseases and the feasibility of metformin as an agent to extend lifespan and healthspan. Finally, we discussed new research directions to better understand the translational potential of metformin in humans. JKL International LLC 2022-07-11 /pmc/articles/PMC9286921/ /pubmed/35855344 http://dx.doi.org/10.14336/AD.2021.1213 Text en copyright: © 2022 Cheng et al. https://creativecommons.org/licenses/by/2.0/this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Commentary
Cheng, Fang-Fang
Liu, Yan-Li
Du, Jang
Lin, Jun-Tang
Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease
title Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease
title_full Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease
title_fullStr Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease
title_full_unstemmed Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease
title_short Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease
title_sort metformin's mechanisms in attenuating hallmarks of aging and age-related disease
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286921/
https://www.ncbi.nlm.nih.gov/pubmed/35855344
http://dx.doi.org/10.14336/AD.2021.1213
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