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Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease
Aging is a major global challenge, and there is growing demand for new strategies to address the burden of aging. The intensive search for antiaging agents has led to the discovery of a variety of drugs that promote the extension of healthspan and/or life. Metformin is a safe, effective, and globall...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286921/ https://www.ncbi.nlm.nih.gov/pubmed/35855344 http://dx.doi.org/10.14336/AD.2021.1213 |
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author | Cheng, Fang-Fang Liu, Yan-Li Du, Jang Lin, Jun-Tang |
author_facet | Cheng, Fang-Fang Liu, Yan-Li Du, Jang Lin, Jun-Tang |
author_sort | Cheng, Fang-Fang |
collection | PubMed |
description | Aging is a major global challenge, and there is growing demand for new strategies to address the burden of aging. The intensive search for antiaging agents has led to the discovery of a variety of drugs that promote the extension of healthspan and/or life. Metformin is a safe, effective, and globally affordable antihyperglycemic agent that has gained much attention in recent years as a potential antiaging treatment. Metformin has been shown to significantly delay the onset of age-related diseases and increase lifespan in several model organisms. In this paper, we reviewed aging hallmarks and the role of metformin in countering these hallmarks. We examined the beneficial effects of metformin on several age-related diseases and the feasibility of metformin as an agent to extend lifespan and healthspan. Finally, we discussed new research directions to better understand the translational potential of metformin in humans. |
format | Online Article Text |
id | pubmed-9286921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | JKL International LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-92869212022-07-18 Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease Cheng, Fang-Fang Liu, Yan-Li Du, Jang Lin, Jun-Tang Aging Dis Commentary Aging is a major global challenge, and there is growing demand for new strategies to address the burden of aging. The intensive search for antiaging agents has led to the discovery of a variety of drugs that promote the extension of healthspan and/or life. Metformin is a safe, effective, and globally affordable antihyperglycemic agent that has gained much attention in recent years as a potential antiaging treatment. Metformin has been shown to significantly delay the onset of age-related diseases and increase lifespan in several model organisms. In this paper, we reviewed aging hallmarks and the role of metformin in countering these hallmarks. We examined the beneficial effects of metformin on several age-related diseases and the feasibility of metformin as an agent to extend lifespan and healthspan. Finally, we discussed new research directions to better understand the translational potential of metformin in humans. JKL International LLC 2022-07-11 /pmc/articles/PMC9286921/ /pubmed/35855344 http://dx.doi.org/10.14336/AD.2021.1213 Text en copyright: © 2022 Cheng et al. https://creativecommons.org/licenses/by/2.0/this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Commentary Cheng, Fang-Fang Liu, Yan-Li Du, Jang Lin, Jun-Tang Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease |
title | Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease |
title_full | Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease |
title_fullStr | Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease |
title_full_unstemmed | Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease |
title_short | Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease |
title_sort | metformin's mechanisms in attenuating hallmarks of aging and age-related disease |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286921/ https://www.ncbi.nlm.nih.gov/pubmed/35855344 http://dx.doi.org/10.14336/AD.2021.1213 |
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