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Prohibitins: A Key Link between Mitochondria and Nervous System Diseases

Prohibitins (PHBs) are conserved proteins in eukaryotic cells, which are mainly located in the inner mitochondrial membrane (IMM), cell nucleus, and cell membrane. PHBs play crucial roles in various cellular functions, including the cell cycle regulation, tumor suppression, immunoglobulin M receptor...

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Detalles Bibliográficos
Autores principales: Jiang, Tianlin, Wang, Jiahua, Li, Chao, Cao, Guiyun, Wang, Xiaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286927/
https://www.ncbi.nlm.nih.gov/pubmed/35847581
http://dx.doi.org/10.1155/2022/7494863
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author Jiang, Tianlin
Wang, Jiahua
Li, Chao
Cao, Guiyun
Wang, Xiaohong
author_facet Jiang, Tianlin
Wang, Jiahua
Li, Chao
Cao, Guiyun
Wang, Xiaohong
author_sort Jiang, Tianlin
collection PubMed
description Prohibitins (PHBs) are conserved proteins in eukaryotic cells, which are mainly located in the inner mitochondrial membrane (IMM), cell nucleus, and cell membrane. PHBs play crucial roles in various cellular functions, including the cell cycle regulation, tumor suppression, immunoglobulin M receptor binding, and aging. In addition, recent in vitro and in vivo studies have revealed that PHBs are important in nervous system diseases. PHBs can prevent apoptosis, inflammation, mitochondrial dysfunction, and autophagy in neurological disorders through different molecules and pathways, such as OPA-1, PINK1/Parkin, IL6/STAT3, Tau, NO, LC3, and TDP43. Therefore, PHBs show great promise in the protection of neurological disorders. This review summarizes the relevant studies on the relationship between PHBs and neurological disorders and provides an update on the molecular mechanisms of PHBs in nervous system diseases.
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spelling pubmed-92869272022-07-16 Prohibitins: A Key Link between Mitochondria and Nervous System Diseases Jiang, Tianlin Wang, Jiahua Li, Chao Cao, Guiyun Wang, Xiaohong Oxid Med Cell Longev Review Article Prohibitins (PHBs) are conserved proteins in eukaryotic cells, which are mainly located in the inner mitochondrial membrane (IMM), cell nucleus, and cell membrane. PHBs play crucial roles in various cellular functions, including the cell cycle regulation, tumor suppression, immunoglobulin M receptor binding, and aging. In addition, recent in vitro and in vivo studies have revealed that PHBs are important in nervous system diseases. PHBs can prevent apoptosis, inflammation, mitochondrial dysfunction, and autophagy in neurological disorders through different molecules and pathways, such as OPA-1, PINK1/Parkin, IL6/STAT3, Tau, NO, LC3, and TDP43. Therefore, PHBs show great promise in the protection of neurological disorders. This review summarizes the relevant studies on the relationship between PHBs and neurological disorders and provides an update on the molecular mechanisms of PHBs in nervous system diseases. Hindawi 2022-07-08 /pmc/articles/PMC9286927/ /pubmed/35847581 http://dx.doi.org/10.1155/2022/7494863 Text en Copyright © 2022 Tianlin Jiang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jiang, Tianlin
Wang, Jiahua
Li, Chao
Cao, Guiyun
Wang, Xiaohong
Prohibitins: A Key Link between Mitochondria and Nervous System Diseases
title Prohibitins: A Key Link between Mitochondria and Nervous System Diseases
title_full Prohibitins: A Key Link between Mitochondria and Nervous System Diseases
title_fullStr Prohibitins: A Key Link between Mitochondria and Nervous System Diseases
title_full_unstemmed Prohibitins: A Key Link between Mitochondria and Nervous System Diseases
title_short Prohibitins: A Key Link between Mitochondria and Nervous System Diseases
title_sort prohibitins: a key link between mitochondria and nervous system diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286927/
https://www.ncbi.nlm.nih.gov/pubmed/35847581
http://dx.doi.org/10.1155/2022/7494863
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