Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina

Calcium channel blocker- (CCB-) associated peripheral edema does not resolve without CCB discontinuation or dose reduction. However, renin–angiotensin system (RAS) inhibitors have been reported to be effective for CCB-associated edema. We report a case of vasospastic angina with refractory CCB-assoc...

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Detalles Bibliográficos
Autores principales: Toda, Kojiro, Fujino, Masashi, Murai, Kota, Noguchi, Teruo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286935/
https://www.ncbi.nlm.nih.gov/pubmed/35845175
http://dx.doi.org/10.1155/2022/9550006
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author Toda, Kojiro
Fujino, Masashi
Murai, Kota
Noguchi, Teruo
author_facet Toda, Kojiro
Fujino, Masashi
Murai, Kota
Noguchi, Teruo
author_sort Toda, Kojiro
collection PubMed
description Calcium channel blocker- (CCB-) associated peripheral edema does not resolve without CCB discontinuation or dose reduction. However, renin–angiotensin system (RAS) inhibitors have been reported to be effective for CCB-associated edema. We report a case of vasospastic angina with refractory CCB-associated edema. A 78-year-old man had refractory edema induced by a CCB. It was successfully treated with tolvaptan, an active vasopressin V2 receptor antagonist. The aim of this case report is to understand the mechanism and treatment of CCB-associated peripheral edema and how tolvaptan affects peripheral edema.
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spelling pubmed-92869352022-07-16 Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina Toda, Kojiro Fujino, Masashi Murai, Kota Noguchi, Teruo Case Rep Cardiol Case Report Calcium channel blocker- (CCB-) associated peripheral edema does not resolve without CCB discontinuation or dose reduction. However, renin–angiotensin system (RAS) inhibitors have been reported to be effective for CCB-associated edema. We report a case of vasospastic angina with refractory CCB-associated edema. A 78-year-old man had refractory edema induced by a CCB. It was successfully treated with tolvaptan, an active vasopressin V2 receptor antagonist. The aim of this case report is to understand the mechanism and treatment of CCB-associated peripheral edema and how tolvaptan affects peripheral edema. Hindawi 2022-07-08 /pmc/articles/PMC9286935/ /pubmed/35845175 http://dx.doi.org/10.1155/2022/9550006 Text en Copyright © 2022 Kojiro Toda et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Toda, Kojiro
Fujino, Masashi
Murai, Kota
Noguchi, Teruo
Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina
title Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina
title_full Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina
title_fullStr Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina
title_full_unstemmed Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina
title_short Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina
title_sort therapeutic potential of a vasopressin v2 receptor antagonist for calcium channel blocker-associated edema with vasospastic angina
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286935/
https://www.ncbi.nlm.nih.gov/pubmed/35845175
http://dx.doi.org/10.1155/2022/9550006
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