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Evidence of Stem Cells Mobilization in the Blood of Patients with Pancreatitis: A Potential Link with Disease Severity

A growing number of studies indicate the potential involvement of various populations of bone marrow-derived stem cells (BMSCs) in tissue repair. However, the mobilization of BMSCs to the peripheral blood (PB) in acute and chronic pancreatitis (AP and CP) has not been investigated. A total of 78 pat...

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Autores principales: Dąbkowski, Krzysztof, Łabędź-Masłowska, Anna, Dołęgowska, Barbara, Safranow, Krzysztof, Budkowska, Marta, Zuba-Surma, Ewa, Starzyńska, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286984/
https://www.ncbi.nlm.nih.gov/pubmed/35846982
http://dx.doi.org/10.1155/2022/5395248
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author Dąbkowski, Krzysztof
Łabędź-Masłowska, Anna
Dołęgowska, Barbara
Safranow, Krzysztof
Budkowska, Marta
Zuba-Surma, Ewa
Starzyńska, Teresa
author_facet Dąbkowski, Krzysztof
Łabędź-Masłowska, Anna
Dołęgowska, Barbara
Safranow, Krzysztof
Budkowska, Marta
Zuba-Surma, Ewa
Starzyńska, Teresa
author_sort Dąbkowski, Krzysztof
collection PubMed
description A growing number of studies indicate the potential involvement of various populations of bone marrow-derived stem cells (BMSCs) in tissue repair. However, the mobilization of BMSCs to the peripheral blood (PB) in acute and chronic pancreatitis (AP and CP) has not been investigated. A total of 78 patients were assigned into AP, CP, and healthy control groups in this study. Using flow cytometry, we found that VSELs, EPCs, and CD133(+)SCs were mobilized to the PB of patients with both AP and CP. Interestingly, AP and CP patients exhibited lower absolute number of circulating MSCs in the PB compared to healthy individuals. SC mobilization to the PB was more evident in patients with AP than CP and in patients with moderate/severe AP than mild AP. Using ELISA, we found a significantly increased HGF concentration in the PB of patients with AP and SDF1α in the PB of patients with CP. We noted a significant positive correlation between SDF1α concentration and the mobilized population of CD133(+)SCs in AP and between C5a and the mobilized population of VSELs moderate/severe AP. Thus, bone marrow-derived SCs may play a role in the regeneration of pancreatic tissue in both AP and CP, and mobilization of VSELs to the PB depends on the severity of AP.
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spelling pubmed-92869842022-07-16 Evidence of Stem Cells Mobilization in the Blood of Patients with Pancreatitis: A Potential Link with Disease Severity Dąbkowski, Krzysztof Łabędź-Masłowska, Anna Dołęgowska, Barbara Safranow, Krzysztof Budkowska, Marta Zuba-Surma, Ewa Starzyńska, Teresa Stem Cells Int Research Article A growing number of studies indicate the potential involvement of various populations of bone marrow-derived stem cells (BMSCs) in tissue repair. However, the mobilization of BMSCs to the peripheral blood (PB) in acute and chronic pancreatitis (AP and CP) has not been investigated. A total of 78 patients were assigned into AP, CP, and healthy control groups in this study. Using flow cytometry, we found that VSELs, EPCs, and CD133(+)SCs were mobilized to the PB of patients with both AP and CP. Interestingly, AP and CP patients exhibited lower absolute number of circulating MSCs in the PB compared to healthy individuals. SC mobilization to the PB was more evident in patients with AP than CP and in patients with moderate/severe AP than mild AP. Using ELISA, we found a significantly increased HGF concentration in the PB of patients with AP and SDF1α in the PB of patients with CP. We noted a significant positive correlation between SDF1α concentration and the mobilized population of CD133(+)SCs in AP and between C5a and the mobilized population of VSELs moderate/severe AP. Thus, bone marrow-derived SCs may play a role in the regeneration of pancreatic tissue in both AP and CP, and mobilization of VSELs to the PB depends on the severity of AP. Hindawi 2022-07-08 /pmc/articles/PMC9286984/ /pubmed/35846982 http://dx.doi.org/10.1155/2022/5395248 Text en Copyright © 2022 Krzysztof Dąbkowski et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dąbkowski, Krzysztof
Łabędź-Masłowska, Anna
Dołęgowska, Barbara
Safranow, Krzysztof
Budkowska, Marta
Zuba-Surma, Ewa
Starzyńska, Teresa
Evidence of Stem Cells Mobilization in the Blood of Patients with Pancreatitis: A Potential Link with Disease Severity
title Evidence of Stem Cells Mobilization in the Blood of Patients with Pancreatitis: A Potential Link with Disease Severity
title_full Evidence of Stem Cells Mobilization in the Blood of Patients with Pancreatitis: A Potential Link with Disease Severity
title_fullStr Evidence of Stem Cells Mobilization in the Blood of Patients with Pancreatitis: A Potential Link with Disease Severity
title_full_unstemmed Evidence of Stem Cells Mobilization in the Blood of Patients with Pancreatitis: A Potential Link with Disease Severity
title_short Evidence of Stem Cells Mobilization in the Blood of Patients with Pancreatitis: A Potential Link with Disease Severity
title_sort evidence of stem cells mobilization in the blood of patients with pancreatitis: a potential link with disease severity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286984/
https://www.ncbi.nlm.nih.gov/pubmed/35846982
http://dx.doi.org/10.1155/2022/5395248
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