Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8(+) T cell responses

Dual blockade of the PD-1 and TIGIT coinhibitory receptors on T cells shows promising early results in cancer patients. Here, we studied the mechanisms whereby PD-1 and/or TIGIT blockade modulate anti-tumor CD8(+) T cells. Although PD-1 and TIGIT are thought to regulate different costimulatory recep...

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Detalles Bibliográficos
Autores principales: Banta, Karl L., Xu, Xiaozheng, Chitre, Avantika S., Au-Yeung, Amelia, Takahashi, Chikara, O’Gorman, William E., Wu, Thomas D., Mittman, Stephanie, Cubas, Rafael, Comps-Agrar, Laetitia, Fulzele, Amit, Bennett, Eric J., Grogan, Jane L., Hui, Enfu, Chiang, Eugene Y., Mellman, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287124/
https://www.ncbi.nlm.nih.gov/pubmed/35263569
http://dx.doi.org/10.1016/j.immuni.2022.02.005

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